TY - JOUR
T1 - Reproducibility and Biological Basis of In Vivo T-2* Magnetic Resonance Imaging of Liver Metastasis of Colorectal Cancer
AU - ter Voert, E. G. W.
AU - Heijmen, L.
AU - de Wilt, J. H. W.
AU - Bussink, J.
AU - Punt, C. J. A.
AU - van Laarhoven, H. W. M.
AU - Heerschap, A.
PY - 2013
Y1 - 2013
N2 - In this study, the reproducibility of T-2* MR imaging in colorectal liver metastases was assessed and T-2* values were correlated with the expression of the hypoxia-related markers GLUT-1 and CA-IX as well as the relative vascular area, and the vessel density in resected tumors. The reproducibility of T-2* was analyzed in 18 patients with in total 22 colorectal liver metastases using the Bland and Altman method for the 16th, 50th, and 84th percentile values. Immunohistochemical staining was performed on 17 resected tumors obtained from 16 patients. The median T-2* of all liver metastases was 25.0 +/- 5.6 ms vs. 23.0 +/- 4.1 ms (median +/- st.dev.) in normal liver. The coefficient of repeatability was 11.2 ms and the limits of agreement were -13.2 ms and 9.1 ms for median T-2* values. On average, T-2* showed fair reproducibility. No correlations between T-2* values, hypoxia-and vascularity-related markers were observed. (C) 2012 Wiley Periodicals, Inc
AB - In this study, the reproducibility of T-2* MR imaging in colorectal liver metastases was assessed and T-2* values were correlated with the expression of the hypoxia-related markers GLUT-1 and CA-IX as well as the relative vascular area, and the vessel density in resected tumors. The reproducibility of T-2* was analyzed in 18 patients with in total 22 colorectal liver metastases using the Bland and Altman method for the 16th, 50th, and 84th percentile values. Immunohistochemical staining was performed on 17 resected tumors obtained from 16 patients. The median T-2* of all liver metastases was 25.0 +/- 5.6 ms vs. 23.0 +/- 4.1 ms (median +/- st.dev.) in normal liver. The coefficient of repeatability was 11.2 ms and the limits of agreement were -13.2 ms and 9.1 ms for median T-2* values. On average, T-2* showed fair reproducibility. No correlations between T-2* values, hypoxia-and vascularity-related markers were observed. (C) 2012 Wiley Periodicals, Inc
U2 - https://doi.org/10.1002/mrm.24543
DO - https://doi.org/10.1002/mrm.24543
M3 - Article
C2 - 23165899
SN - 0740-3194
VL - 70
SP - 1145
EP - 1152
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 4
ER -