TY - JOUR
T1 - Residual solvent analysis by gas chromatography in radiopharmaceutical formulations containing up to 12% ethanol
AU - Klok, Robert P.
AU - Windhorst, Albert D.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - For the detection and quantification of residual solvents in solutions of radiopharmaceuticals for human applications, a new analysis method was set up. With a simple direct gas chromatography injection, no special sample treatments or special injection techniques (such as head-space or solid-phase microextraction) are necessary. This method is especially suited for the fast and quantitative analysis of residual solvents in radiopharmaceutical formulations where 5-12% ethanol is present. The method proved to be both accurate and linear. The quantification limit is in the lower parts-per-million range, which is sufficient given the need for a fast analysis and the maximally allowed concentration for these residual solvents.
AB - For the detection and quantification of residual solvents in solutions of radiopharmaceuticals for human applications, a new analysis method was set up. With a simple direct gas chromatography injection, no special sample treatments or special injection techniques (such as head-space or solid-phase microextraction) are necessary. This method is especially suited for the fast and quantitative analysis of residual solvents in radiopharmaceutical formulations where 5-12% ethanol is present. The method proved to be both accurate and linear. The quantification limit is in the lower parts-per-million range, which is sufficient given the need for a fast analysis and the maximally allowed concentration for these residual solvents.
KW - Gas chromatography
KW - Radiopharmaceutical formulation
KW - Residual solvent
KW - Volatile organic compound
UR - http://www.scopus.com/inward/record.url?scp=33749433218&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.nucmedbio.2006.07.003
DO - https://doi.org/10.1016/j.nucmedbio.2006.07.003
M3 - Article
C2 - 17045174
SN - 0969-8051
VL - 33
SP - 935
EP - 938
JO - Nuclear medicine and biology
JF - Nuclear medicine and biology
IS - 7
ER -