TY - JOUR
T1 - Resistance to erythropoiesis stimulating agents in patients treated with online hemodiafiltration and ultrapure low-flux hemodialysis: results from a randomized controlled trial (CONTRAST)
AU - van der Weerd, Neelke C.
AU - den Hoedt, Claire H.
AU - Blankestijn, Peter J.
AU - Bots, Michiel L.
AU - van den Dorpel, Marinus A.
AU - Lévesque, Renée
AU - Mazairac, Albert H. A.
AU - Nubé, Menso J.
AU - Penne, E. Lars
AU - ter Wee, Pieter M.
AU - Grooteman, Muriel P. C.
AU - AUTHOR GROUP
AU - Blankestijn, P. J.
AU - Bots, M. L.
AU - Centrum, Julius
AU - van den Dorpel, M. A.
AU - Grooteman, M. P. C.
AU - Nubé, M. J.
AU - ter Wee, P. M.
AU - Dorval, M.
AU - Lévesque, R.
AU - Koopman, M. G.
AU - Konings, C. J. A. M.
AU - Haanstra, W. P.
AU - Kooistra, M.
AU - van Jaarsveld, B.
AU - Noordzij, T.
AU - Feith, G. W.
AU - Peltenburg, H. G.
AU - van Buren, M.
AU - Offerman, J. J. G.
AU - Bosch, Jeroen
AU - Hoogeveen, E. K.
AU - de Heer, F.
AU - van de Ven, P. J.
AU - Hovinga, T. K. Kremer
AU - Bax, W. A.
AU - Groeneveld, J. O.
AU - Lavrijssen, A. T. J.
AU - Schrander-van der Meer, A. M.
AU - Reichert, L. J. M.
AU - Huussen, J.
AU - Rensma, P. L.
AU - Schrama, Y.
AU - van Hamersvelt, H. W.
AU - Boer, W. H.
AU - van Kuijk, W. H.
AU - Vervloet, M. G.
AU - Wauters, I. M. P. M. J.
AU - Sekse, I.
PY - 2014
Y1 - 2014
N2 - Resistance to erythropoiesis stimulating agents (ESA) is common in patients undergoing chronic hemodialysis (HD) treatment. ESA responsiveness might be improved by enhanced clearance of uremic toxins of middle molecular weight, as can be obtained by hemodiafiltration (HDF). In this analysis of the randomized controlled CONvective TRAnsport STudy (CONTRAST; NCT00205556), the effect of online HDF on ESA resistance and iron parameters was studied. This was a pre-specified secondary endpoint of the main trial. A 12 months' analysis of 714 patients randomized to either treatment with online post-dilution HDF or continuation of low-flux HD was performed. Both groups were treated with ultrapure dialysis fluids. ESA resistance, measured every three months, was expressed as the ESA index (weight adjusted weekly ESA dose in daily defined doses [DDD]/hematocrit). The mean ESA index during 12 months was not different between patients treated with HDF or HD (mean difference HDF versus HD over time 0.029 DDD/kg/Hct/week [-0.024 to 0.081]; P = 0.29). Mean transferrin saturation ratio and ferritin levels during the study tended to be lower in patients treated with HDF (-2.52% [-4.72 to -0.31]; P = 0.02 and -49 ng/mL [-103 to 4]; P = 0.06 respectively), although there was a trend for those patients to receive slightly more iron supplementation (7.1 mg/week [-0.4 to 14.5]; P = 0.06). In conclusion, compared to low-flux HD with ultrapure dialysis fluid, treatment with online HDF did not result in a decrease in ESA resistance. ClinicalTrials.gov NCT00205556
AB - Resistance to erythropoiesis stimulating agents (ESA) is common in patients undergoing chronic hemodialysis (HD) treatment. ESA responsiveness might be improved by enhanced clearance of uremic toxins of middle molecular weight, as can be obtained by hemodiafiltration (HDF). In this analysis of the randomized controlled CONvective TRAnsport STudy (CONTRAST; NCT00205556), the effect of online HDF on ESA resistance and iron parameters was studied. This was a pre-specified secondary endpoint of the main trial. A 12 months' analysis of 714 patients randomized to either treatment with online post-dilution HDF or continuation of low-flux HD was performed. Both groups were treated with ultrapure dialysis fluids. ESA resistance, measured every three months, was expressed as the ESA index (weight adjusted weekly ESA dose in daily defined doses [DDD]/hematocrit). The mean ESA index during 12 months was not different between patients treated with HDF or HD (mean difference HDF versus HD over time 0.029 DDD/kg/Hct/week [-0.024 to 0.081]; P = 0.29). Mean transferrin saturation ratio and ferritin levels during the study tended to be lower in patients treated with HDF (-2.52% [-4.72 to -0.31]; P = 0.02 and -49 ng/mL [-103 to 4]; P = 0.06 respectively), although there was a trend for those patients to receive slightly more iron supplementation (7.1 mg/week [-0.4 to 14.5]; P = 0.06). In conclusion, compared to low-flux HD with ultrapure dialysis fluid, treatment with online HDF did not result in a decrease in ESA resistance. ClinicalTrials.gov NCT00205556
U2 - https://doi.org/10.1371/journal.pone.0094434
DO - https://doi.org/10.1371/journal.pone.0094434
M3 - Article
C2 - 24743493
SN - 1932-6203
VL - 9
SP - e94434
JO - PLoS ONE
JF - PLoS ONE
IS - 4
M1 - e94434
ER -