Retroviral microRNAs

Alex Harwig; Atze T. Das; Ben Berkhout

doi:https://doi.org/10.1016/j.coviro.2014.03.013

Retroviral microRNAs

Alex Harwig, Atze T. Das, Ben Berkhout

Medical Microbiology and Infection Prevention (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

38 Citations (Scopus)

Abstract

Eukaryotic cells and several DNA viruses encode miRNAs to regulate the expression of specific target genes. It has been controversial whether RNA viruses can encode such miRNAs as miRNA excision may lead to cleavage of the viral RNA genome. We will focus on the retrovirus family, HIV-1 in particular, and discuss the production of virus-encoded miRNAs and their putative function in the viral replication cycle. An intricate scenario of multi-layer virus-host interactions becomes apparent with small RNAs as the regulatory molecules

Original language	English
Pages (from-to)	47-54
Journal	Current opinion in virology
Volume	7
DOIs	https://doi.org/10.1016/j.coviro.2014.03.013
Publication status	Published - 2014

Access to Document

https://doi.org/10.1016/j.coviro.2014.03.013

Cite this

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title = "Retroviral microRNAs",

abstract = "Eukaryotic cells and several DNA viruses encode miRNAs to regulate the expression of specific target genes. It has been controversial whether RNA viruses can encode such miRNAs as miRNA excision may lead to cleavage of the viral RNA genome. We will focus on the retrovirus family, HIV-1 in particular, and discuss the production of virus-encoded miRNAs and their putative function in the viral replication cycle. An intricate scenario of multi-layer virus-host interactions becomes apparent with small RNAs as the regulatory molecules",

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AU - Das, Atze T.

AU - Berkhout, Ben

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AB - Eukaryotic cells and several DNA viruses encode miRNAs to regulate the expression of specific target genes. It has been controversial whether RNA viruses can encode such miRNAs as miRNA excision may lead to cleavage of the viral RNA genome. We will focus on the retrovirus family, HIV-1 in particular, and discuss the production of virus-encoded miRNAs and their putative function in the viral replication cycle. An intricate scenario of multi-layer virus-host interactions becomes apparent with small RNAs as the regulatory molecules

U2 - https://doi.org/10.1016/j.coviro.2014.03.013

DO - https://doi.org/10.1016/j.coviro.2014.03.013

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SP - 47

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JO - Current opinion in virology

JF - Current opinion in virology

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