TY - JOUR
T1 - Reverse Cholesterol Transport Revisited Contribution of Biliary Versus Intestinal Cholesterol Excretion
AU - Brufau, Gemma
AU - Groen, Albert K.
AU - Kuipers, Folkert
PY - 2011
Y1 - 2011
N2 - Reverse cholesterol transport (RCT) is usually defined as high-density lipoprotein-mediated transport of excess cholesterol from peripheral tissues, including cholesterol-laden macrophages in vessel walls, to the liver. From the liver, cholesterol can then be removed from the body via secretion into the bile for eventual disposal via the feces. According to this paradigm, high plasma high-density lipoprotein levels accelerate RCT and hence are atheroprotective. New insights in individual steps of the RCT pathway, in part derived from innovative mouse models, indicate that the classical concept of RCT may require modification. (Arterioscler Thromb Vasc Biol. 2011;31:1726-1733.)
AB - Reverse cholesterol transport (RCT) is usually defined as high-density lipoprotein-mediated transport of excess cholesterol from peripheral tissues, including cholesterol-laden macrophages in vessel walls, to the liver. From the liver, cholesterol can then be removed from the body via secretion into the bile for eventual disposal via the feces. According to this paradigm, high plasma high-density lipoprotein levels accelerate RCT and hence are atheroprotective. New insights in individual steps of the RCT pathway, in part derived from innovative mouse models, indicate that the classical concept of RCT may require modification. (Arterioscler Thromb Vasc Biol. 2011;31:1726-1733.)
U2 - https://doi.org/10.1161/ATVBAHA.108.181206
DO - https://doi.org/10.1161/ATVBAHA.108.181206
M3 - Review article
C2 - 21571685
SN - 1079-5642
VL - 31
SP - 1726
EP - 1733
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 8
ER -