Reversibele neurologische uitval jaren na hooggradig glioom: het SMART-syndroom

Fonnet E. Bleeker, Joseph C. J. Bot, Hanneke E. Ronner, Tjeerd J. Postma

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Survival in patients with high grade glioma has been extended in recent years as a result of more intensive therapy. As a consequence, more late term complications of treatment may be observed. A 69-year-old woman presented at the outpatient department of Neurology with headache and loss of strength in the left arm. She had been treated 7 years previously for a high grade glioma with resection and radiotherapy. One year later she had received chemotherapy for a local recurrence. Since then she was free of complaints. At investigation a left sided hemiparesis was found. As recurrence of the tumour was suspected, MR imaging of the brain was performed, which showed abnormalities suggestive for the so called 'stroke-like migraine attacks after radiotherapy' (SMART) syndrome. The further clinical course, with spontaneous recovery of strength within a few weeks and the regression of the cortical hyperintensity on MRI, confirmed the probable diagnosis. The SMART syndrome is a relatively unknown condition and should be included in the differential diagnosis in patients who present with new complaints long after cerebral radiotherapy
Original languageDutch
Pages (from-to)A4704
JournalNederlands Tijdschrift voor Geneeskunde
Issue number29
Publication statusPublished - 2012

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