Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients

C.T. Gan, S. Holverda, J.T. Marcus, W.J.S. Paulus, K.M. Marques, J.G.F. Bronzwaer, J.W.R. Twisk, A. Boonstra, P.E. Postmus, A. Vonk Noordegraaf

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126 Citations (Scopus)

Abstract

Aims: This study investigated whether right ventricular (RV) diastolic function is impaired in pulmonary hypertension (PH) patients, and whether it is related to RV mass and afterload. In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity. Methods and results: Twenty-five PH patients and 11 control subjects were studied. Right-heart catheterization and N-terminal pro-brain natriuretic peptide (NT-proBNP) sampling were performed in patients. MRI measured RV ejection fraction, mass, and diastolic function. Isovolumic relaxation time (IVRT), normalized early peak filling rate (E), atrium-induced peak filling rate (A), and E/A ratio described diastolic function. Compared to control subjects, patients had prolonged mean (± SD) IVRT (133.5 ± 53.2 vs 29.3 ± 20.8 ms, respectively; p < 0.001), decreased E (3.0 ± 1.6 vs 6.4 ± 2.5 s
Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalChest
Volume132
Issue number1
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Adult
  • Antihypertensive Agents/therapeutic use
  • Blood Circulation/physiology
  • Blood Pressure/physiology
  • Epoprostenol/therapeutic use
  • Female
  • Heart Ventricles/pathology
  • Humans
  • Hypertension, Pulmonary/drug therapy
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nitric Oxide/therapeutic use
  • Piperazines/therapeutic use
  • Purines/therapeutic use
  • Severity of Illness Index
  • Sildenafil Citrate
  • Stroke Volume/physiology
  • Sulfonamides/therapeutic use
  • Sulfones/therapeutic use
  • Vascular Resistance/physiology
  • Vasodilator Agents/therapeutic use
  • Ventricular Dysfunction, Right/physiopathology

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