Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.

HF Wertheim; MC Vos; A Ott; A. van Belkum; A Voss; J.A. Kluytmans; PH van Keulen; C.M.J.E. Vandenbroucke-Grauls; MH Meester; H.A. Verbrugh; Heiman F. L. Wertheim; Margreet C. Vos; Peter H. J. van Keulen

doi:https://doi.org/10.1016/S0140-6736(04)16897-9

Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.

HF Wertheim, MC Vos, A Ott, A. van Belkum, A Voss, J.A. Kluytmans, PH van Keulen, C.M.J.E. Vandenbroucke-Grauls, MH Meester, H.A. Verbrugh, Heiman F. L. Wertheim, Margreet C. Vos, Peter H. J. van Keulen

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Abstract

Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous

Original language	English
Pages (from-to)	703-5
Journal	Lancet
Volume	364
Issue number	9435
DOIs	https://doi.org/10.1016/S0140-6736(04)16897-9
Publication status	Published - 2004

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https://doi.org/10.1016/S0140-6736(04)16897-9

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Wertheim, HF., Vos, MC., Ott, A., van Belkum, A., Voss, A., Kluytmans, J. A., van Keulen, PH., Vandenbroucke-Grauls, C. M. J. E., Meester, MH., Verbrugh, H. A., Wertheim, H. F. L., Vos, M. C., & van Keulen, P. H. J. (2004). Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Lancet, 364(9435), 703-5. https://doi.org/10.1016/S0140-6736(04)16897-9

@article{2fe1348274a14e4bb21cfed8b6bcd22a,

title = "Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.",

abstract = "Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous",

author = "HF Wertheim and MC Vos and A Ott and {van Belkum}, A. and A Voss and J.A. Kluytmans and {van Keulen}, PH and C.M.J.E. Vandenbroucke-Grauls and MH Meester and H.A. Verbrugh and Wertheim, {Heiman F. L.} and Vos, {Margreet C.} and {van Keulen}, {Peter H. J.}",

year = "2004",

doi = "https://doi.org/10.1016/S0140-6736(04)16897-9",

language = "English",

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Wertheim, HF, Vos, MC, Ott, A, van Belkum, A, Voss, A, Kluytmans, JA, van Keulen, PH, Vandenbroucke-Grauls, CMJE, Meester, MH, Verbrugh, HA, Wertheim, HFL, Vos, MC & van Keulen, PHJ 2004, 'Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.', Lancet, vol. 364, no. 9435, pp. 703-5. https://doi.org/10.1016/S0140-6736(04)16897-9

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T1 - Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers.

AU - Wertheim, HF

AU - Vos, MC

AU - Ott, A

AU - van Belkum, A.

AU - Voss, A

AU - Kluytmans, J.A.

AU - van Keulen, PH

AU - Vandenbroucke-Grauls, C.M.J.E.

AU - Meester, MH

AU - Verbrugh, H.A.

AU - Wertheim, Heiman F. L.

AU - Vos, Margreet C.

AU - van Keulen, Peter H. J.

PY - 2004

Y1 - 2004

N2 - Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous

AB - Staphylococcus aureus is the second most frequent cause of nosocomial blood infections. We screened 14008 non-bacteraemic, non-surgical patients for S aureus nasal carriage at admission, and monitored them for development of bacteraemia. Nosocomial S aureus bacteraemia was three times more frequent in S aureus carriers (40/3420, 1.2%) than in non-carriers (41/10588, 0.4%; relative risk 3.0, 95% CI 2.0-4.7). However, in bacteraemic patients, all-cause mortality was significantly higher in non-carriers (19/41, 46%) than in carriers (seven/40, 18%, p=0.005). Additionally, S aureus bacteraemia-related death was significantly higher in non-carriers than in carriers (13/41 [32%] vs three/40 [8%], p=0.006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous

U2 - https://doi.org/10.1016/S0140-6736(04)16897-9

DO - https://doi.org/10.1016/S0140-6736(04)16897-9

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SN - 0140-6736

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JO - Lancet

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