Risk factors for local recurrence following conservation therapy in breast cancer

Paula H. M. Elkhuizen, Bas Kreike, Marc J. van de Vijver

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


During recent decades, the surgical approach to treat breast cancer has changed. Through - out most of the 20th century the traditional surgical approach has been the radical or the modified radical mastectomy. The radical mastectomy was introduced by Halsted;1 it included removal of the breast, including an ample amount of the overlying skin, the greater part of the underlying pectoral muscles, all axillary lymph nodes and, in later years, also the supraclavicular nodes in most cases. The Halsted mastectomy was readily accepted due to its good treatment results. In later years it was found that less mutilating surgery, with preservation of the pectoral major muscles or both pectoral muscles (the modified radical mastectomy) was equally effective with regard to locoregional control and survival. From the 1970s onwards, the modified radical mastectomy became the standard surgical treatment of early breast cancer.
Original languageEnglish
Title of host publicationPrognostic and Predictive Factors in Breast Cancer
PublisherCRC Press
ISBN (Electronic)9781439807231
ISBN (Print)0415422256
Publication statusPublished - 2008

Publication series

NamePrognostic and Predictive Factors in Breast Cancer

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