TY - JOUR
T1 - Risk indicators for urinary tract infections in low risk pregnancy and the subsequent risk of preterm birth
AU - Werter, Dominique E.
AU - Kazemier, Brenda M.
AU - Schneeberger, Caroline
AU - Mol, Ben W.J.
AU - de Groot, Christianne J.M.
AU - Geerlings, Suzanne E.
AU - Pajkrt, Eva
N1 - Funding Information: Conflicts of Interest: Ben W.J. Mol is supported by a NHMRC Investigator grant (GNT1176437). Ben W.J. Mol reports consultancy and invited talks for ObsEva, Ferring and Merck. The other authors report no conflict of interest. Funding Information: Funding: This study was funded by ZonMw, the Dutch organization for health research and development, grant number 50-50110-96-530. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Symptomatic urinary tract infections are associated with preterm birth. However, data on risk indicators for urinary tract infections are limited and outdated. The research is a secondary analysis. The study was a prospective multicenter cohort study of low-risk pregnant women. Logistic regression was used to identify risk indicators for urinary tract infections. The incidence of urinary tract infections was 9.4%. Multivariate logistic regression showed that a history of recurrent urinary tract infections and the presence of asymptomatic bacteriuria in the present pregnancy were associated with urinary tract infections (resp. OR 3.14, 95%CI 1.40–7.02 and OR 1.96 95%CI 1.27–3.03). Women with a urinary tract infection were at increased risk of preterm birth compared to women without a urinary tract infection (12 vs. 5.1%; adjusted HR 2.5 95%CI 1.8–3.5). This increased risk was not found in women with the identified risk indicators (resp. 5.3% vs. 5.1%, adjusted HR 0.35 95%CI 0.00–420 and adjusted HR 1.5 95CI% 0.59–3.9). In conclusion, in low-risk pregnant women, risk indicators for urinary tract infections are: a history of recurrent urinary tract infections and the presence of asymptomatic bacteriuria. The risk of preterm birth is increased in women with a urinary tract infection in this pregnancy. However, women with recurrent urinary tract infections and asymptomatic bacteriuria this pregnancy appear not to be at increased risk of preterm birth.
AB - Symptomatic urinary tract infections are associated with preterm birth. However, data on risk indicators for urinary tract infections are limited and outdated. The research is a secondary analysis. The study was a prospective multicenter cohort study of low-risk pregnant women. Logistic regression was used to identify risk indicators for urinary tract infections. The incidence of urinary tract infections was 9.4%. Multivariate logistic regression showed that a history of recurrent urinary tract infections and the presence of asymptomatic bacteriuria in the present pregnancy were associated with urinary tract infections (resp. OR 3.14, 95%CI 1.40–7.02 and OR 1.96 95%CI 1.27–3.03). Women with a urinary tract infection were at increased risk of preterm birth compared to women without a urinary tract infection (12 vs. 5.1%; adjusted HR 2.5 95%CI 1.8–3.5). This increased risk was not found in women with the identified risk indicators (resp. 5.3% vs. 5.1%, adjusted HR 0.35 95%CI 0.00–420 and adjusted HR 1.5 95CI% 0.59–3.9). In conclusion, in low-risk pregnant women, risk indicators for urinary tract infections are: a history of recurrent urinary tract infections and the presence of asymptomatic bacteriuria. The risk of preterm birth is increased in women with a urinary tract infection in this pregnancy. However, women with recurrent urinary tract infections and asymptomatic bacteriuria this pregnancy appear not to be at increased risk of preterm birth.
KW - Asymptomatic bacteriuria
KW - Preterm birth
KW - Recurrent urinary tract infections
KW - Risk indicators
KW - Urinary tract infections
UR - http://www.scopus.com/inward/record.url?scp=85114472747&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/antibiotics10091055
DO - https://doi.org/10.3390/antibiotics10091055
M3 - Article
C2 - 34572637
SN - 2079-6382
VL - 10
JO - Antibiotics
JF - Antibiotics
IS - 9
M1 - 1055
ER -