TY - JOUR
T1 - Risk of Developing Type 2 Diabetes in Individuals With a Psychiatric Disorder
T2 - A Nationwide Register-Based Cohort Study
AU - Lindekilde, Nanna
AU - Scheuer, Stine H.
AU - Diaz, Lars J.
AU - Rubin, Katrine H.
AU - Plana-Ripoll, Oleguer
AU - Henriksen, Jan Erik
AU - Lasgaard, Mathias
AU - Andersen, Gregers S.
AU - Pouwer, Frans
N1 - Funding Information: Funding. This study was funded by an unrestricted PhD grant from the Faculty of Health Sciences, University of Southern Denmark. Duality of Interest. G.S.A. own shares in Novo Nordisk A/S. No other potential conflicts of interest relevant to this article were reported. Author Contributions. N.L. contributed to the design of the study and was responsible Publisher Copyright: © 2022, American Diabetes Association Inc.. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - OBJECTIVE: Previous studies have investigated the incidence of type 2 diabetes in individuals with psychiatric disorders, but most studies have focused on a specific psychiatric disorder or a selected sample. More population-based studies are needed to determine these associations in representative samples. We therefore aimed to determine these associations in a nationwide, register-based dynamic cohort study. RESEARCH DESIGN AND METHODS: We analyzed data from 5,005,612 adults living in Denmark between 1995 and 2018, without prior diabetes. We investigated 10 different categories of psychiatric disorders and a composite group with any psychiatric disorder. Individuals with a psychiatric disorder were compared with individuals without using multivariable-adjusted Poisson regression to estimate incidence rate ratios (IRR) of type 2 diabetes. We modeled age-specific incidence rates (IR) for individuals with and without the specific psychiatric disorder. All models were stratified by sex. RESULTS: In total, 334,739 individuals developed type 2 diabetes during follow-up. For all investigated categories of psychiatric disorders, we found increased IR of type 2 diabetes for individuals with versus those without a psychiatric disorder (IRR: men, 1.47 [95% CI 1.45-1.50]; women, 1.65 [95% CI 1.62-1.68]). When we examined age-specific IR, the largest differences were found in the younger population (<50 years). CONCLUSIONS: We found that the IR of type 2 diabetes was higher in individuals with a psychiatric disorder compared with individuals without a psychiatric disorder and particularly high in the younger people with a psychiatric disorder. New studies into the prevention and early detection of type 2 diabetes in these groups are warranted.
AB - OBJECTIVE: Previous studies have investigated the incidence of type 2 diabetes in individuals with psychiatric disorders, but most studies have focused on a specific psychiatric disorder or a selected sample. More population-based studies are needed to determine these associations in representative samples. We therefore aimed to determine these associations in a nationwide, register-based dynamic cohort study. RESEARCH DESIGN AND METHODS: We analyzed data from 5,005,612 adults living in Denmark between 1995 and 2018, without prior diabetes. We investigated 10 different categories of psychiatric disorders and a composite group with any psychiatric disorder. Individuals with a psychiatric disorder were compared with individuals without using multivariable-adjusted Poisson regression to estimate incidence rate ratios (IRR) of type 2 diabetes. We modeled age-specific incidence rates (IR) for individuals with and without the specific psychiatric disorder. All models were stratified by sex. RESULTS: In total, 334,739 individuals developed type 2 diabetes during follow-up. For all investigated categories of psychiatric disorders, we found increased IR of type 2 diabetes for individuals with versus those without a psychiatric disorder (IRR: men, 1.47 [95% CI 1.45-1.50]; women, 1.65 [95% CI 1.62-1.68]). When we examined age-specific IR, the largest differences were found in the younger population (<50 years). CONCLUSIONS: We found that the IR of type 2 diabetes was higher in individuals with a psychiatric disorder compared with individuals without a psychiatric disorder and particularly high in the younger people with a psychiatric disorder. New studies into the prevention and early detection of type 2 diabetes in these groups are warranted.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85125882800&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35043146
U2 - https://doi.org/10.2337/dc21-1864
DO - https://doi.org/10.2337/dc21-1864
M3 - Article
C2 - 35043146
SN - 0149-5992
VL - 45
SP - 724
EP - 733
JO - Diabetes care
JF - Diabetes care
IS - 3
ER -