Abstract
This prospective, in vivo feasibility study with 20 patients with recurrent prostate cancer (PCa) evaluated whether a miniaturized DROP-IN gamma probe enables robot-assisted prostate-specific membrane antigen (PSMA)-targeted radioguided surgery (RGS; NCT03857113). We included patients with up to three pelvic PCa recurrences (nodal or local) on PSMA positron emission tomography (PET) after previous curative-intent therapy. Robot-assisted PSMA-RGS using the DROP-IN gamma probe was carried out after intravenous injection of a 99mTechnetium-labelled PSMA-ligand (99mTc-PSMA-I&S). The primary endpoint was the feasibility of robot-assisted PSMA-RGS. Using the DROP-IN probe, we were able to robotically resect 19 out of 21 (90%) preoperatively identified lesions. The per-lesion ex vivo sensitivity and specificity of robot-assisted PSMA-RGS was 86% and 100%, respectively. One patient suffered from a Clavien-Dindo grade V complication. We therefore conclude that the DROP-IN probe helps to realize robot-assisted PSMA-RGS. This procedure is technically feasible for the intraoperative detection of both nodal and local PCa recurrences.
Translated title of the contribution | Robot-assisted PSMA-radioguided salvage surgery in recurrent prostate cancer using a DROP-IN gammaprobe: The first prospective feasibility study |
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Original language | Dutch |
Pages (from-to) | 11-20 |
Number of pages | 10 |
Journal | Tijdschrift voor Urologie |
Volume | 13 |
Issue number | 1 |
Early online date | 2022 |
DOIs | |
Publication status | Published - 1 Jan 2023 |
Keywords
- image-guided
- prostate cancer
- prostate-specific membrane antigen
- radioguided
- surgery