Role of biliary proteins and non-protein factors in kinetics of cholesterol crystallisation and gallstone growth

M. Jirsa, A. K. Groen

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)

Abstract

Numerous biliary proteins as well as non-protein factors influence kinetics of cholesterol crystallisation from supersaturated bile. Cholesterol crystallisation pathways, methods used for quantitative evaluation of liquid-to-solid transition of cholesterol in bile and the classical concept of nucleation defect in pathogenesis of gallstones are reviewed in the first part of this article. The relevance of individual biliary proteins and non-protein factors is discussed in the second part. Finally, a new concept according to which accelerated crystallisation of cholesterol inhibits gallstone growth and protects the gallbladder wall from toxic injury resulting from the increased absorption and accumulation of cholesterol from supersaturated bile is suggested
Original languageEnglish
Pages (from-to)E154-E167
JournalFrontiers in bioscience
Volume6
DOIs
Publication statusPublished - 2001

Cite this