Role of Biologics in Chronic Rhinosinusitis With Nasal Polyposis: State of the Art Review

Christine Kim; Joseph Han; Tara Wu; Claus Bachert; Wytske Fokkens; Peter Hellings; Claire Hopkins; Stella Lee; Joaquim Mullol; Jivianne T. Lee

doi:https://doi.org/10.1177/0194599820939964

Role of Biologics in Chronic Rhinosinusitis With Nasal Polyposis: State of the Art Review

Christine Kim, Joseph Han, Tara Wu, Claus Bachert, Wytske Fokkens, Peter Hellings, Claire Hopkins, Stella Lee, Joaquim Mullol, Jivianne T. Lee

Research output: Contribution to journal › Review article › Academic › peer-review

19 Citations (Scopus)

Abstract

Objective: To review the current literature regarding the role of biologics in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Data Sources: PubMed/MEDLINE, EMBASE, Cochrane Review, ClinicalTrials.gov Review Methods: We conducted a comprehensive review of the literature on clinical studies investigating the efficacy of emerging biologics in CRSwNP, with a focus on randomized controlled trials. Conclusions: There appears to be promising evidence to support the safety and efficacy of biologics in CRSwNP with and without asthma for select patients. However, additional large-scale randomized studies with longer follow-up are necessary to determine which patients would benefit the most from these novel systemic treatments. Implications for Practice: Chronic rhinosinusitis with nasal polyposis refractory to medical and surgical therapy remains a challenging clinical problem for otolaryngologists. However, emerging biologic therapies may offer a new therapeutic option for such patients with recalcitrant disease.

Original language	English
Pages (from-to)	57-66
Number of pages	10
Journal	Otolaryngology-Head and Neck Surgery
Volume	164
Issue number	1
Early online date	2020
DOIs	https://doi.org/10.1177/0194599820939964
Publication status	Published - Jan 2021

Keywords

biologics
chronic rhinosinusitis
nasal polyposis

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title = "Role of Biologics in Chronic Rhinosinusitis With Nasal Polyposis: State of the Art Review",

abstract = "Objective: To review the current literature regarding the role of biologics in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Data Sources: PubMed/MEDLINE, EMBASE, Cochrane Review, ClinicalTrials.gov Review Methods: We conducted a comprehensive review of the literature on clinical studies investigating the efficacy of emerging biologics in CRSwNP, with a focus on randomized controlled trials. Conclusions: There appears to be promising evidence to support the safety and efficacy of biologics in CRSwNP with and without asthma for select patients. However, additional large-scale randomized studies with longer follow-up are necessary to determine which patients would benefit the most from these novel systemic treatments. Implications for Practice: Chronic rhinosinusitis with nasal polyposis refractory to medical and surgical therapy remains a challenging clinical problem for otolaryngologists. However, emerging biologic therapies may offer a new therapeutic option for such patients with recalcitrant disease.",

keywords = "biologics, chronic rhinosinusitis, nasal polyposis",

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year = "2021",

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doi = "https://doi.org/10.1177/0194599820939964",

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AU - Fokkens, Wytske

AU - Hellings, Peter

AU - Hopkins, Claire

AU - Lee, Stella

AU - Mullol, Joaquim

AU - Lee, Jivianne T.

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N2 - Objective: To review the current literature regarding the role of biologics in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Data Sources: PubMed/MEDLINE, EMBASE, Cochrane Review, ClinicalTrials.gov Review Methods: We conducted a comprehensive review of the literature on clinical studies investigating the efficacy of emerging biologics in CRSwNP, with a focus on randomized controlled trials. Conclusions: There appears to be promising evidence to support the safety and efficacy of biologics in CRSwNP with and without asthma for select patients. However, additional large-scale randomized studies with longer follow-up are necessary to determine which patients would benefit the most from these novel systemic treatments. Implications for Practice: Chronic rhinosinusitis with nasal polyposis refractory to medical and surgical therapy remains a challenging clinical problem for otolaryngologists. However, emerging biologic therapies may offer a new therapeutic option for such patients with recalcitrant disease.

AB - Objective: To review the current literature regarding the role of biologics in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Data Sources: PubMed/MEDLINE, EMBASE, Cochrane Review, ClinicalTrials.gov Review Methods: We conducted a comprehensive review of the literature on clinical studies investigating the efficacy of emerging biologics in CRSwNP, with a focus on randomized controlled trials. Conclusions: There appears to be promising evidence to support the safety and efficacy of biologics in CRSwNP with and without asthma for select patients. However, additional large-scale randomized studies with longer follow-up are necessary to determine which patients would benefit the most from these novel systemic treatments. Implications for Practice: Chronic rhinosinusitis with nasal polyposis refractory to medical and surgical therapy remains a challenging clinical problem for otolaryngologists. However, emerging biologic therapies may offer a new therapeutic option for such patients with recalcitrant disease.

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Role of Biologics in Chronic Rhinosinusitis With Nasal Polyposis: State of the Art Review

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Keywords

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