Role of copeptin in diagnosis and outcome prediction in patients with heart failure: a systematic review and meta-analysis

Jakub Michal Zimodro, Aleksandra Gasecka, Milosz Jaguszewski, Sandra Amanowicz, Marta Szkiela, Andrea Denegri, Michal Pruc, Piotr Duchnowski, Frank W. Peacock, Zubaid Rafique, Lukasz Szarpak

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Background/Context: Heart failure (HF) is a heterogeneous condition characterized by increased morbidity and mortality. Objective: This systematic review and meta-analysis of 19 studies was conducted to evaluate the role of copeptin in diagnosis and outcome prediction in HF patients. Materials and methods: A systematic literature search for clinical trials reporting copeptin levels in HF patients was performed using EMBASE, PubMed, Cochrane Register of Controlled Trials, and Google Scholar. Articles from databases published by 2 January 2022, that met the selection criteria were retrieved and reviewed. The random effects model was used for analyses. Results: Pooled analysis found higher mean copeptin levels in HF vs. non-HF populations (43.6 ± 46.4 vs. 21.4 ± 21.4; MD= 20.48; 95% CI: 9.22 to 31.74; p < 0.001). Pooled analysis of copeptin concentrations stratified by ejection fraction showed higher concentrations in HFrEF vs. HFpEF (17.4 ± 7.1 vs. 10.1 ± 5.5; MD= −4.69; 95% CI: −7.58 to −1.81; p = 0.001). Copeptin level was higher in patients with mortality/acute HF-related hospitalization vs. stable patients (31.3 ± 23.7 vs. 20.4 ± 12.8; MD= −13.06; 95% CI: −25.28 to −0.84; p = 0.04). Higher copeptin concentrations were associated with mortality and observed in all follow-up periods (p < 0.05). Conclusions: The present meta-analysis showed that elevated copeptin plasma concentrations observed in HF patients are associated with an increased risk of all-cause mortality, thus copeptin may serve as predictor of outcome in HF.

Original languageEnglish
Pages (from-to)720-726
Number of pages7
Issue number8
Early online date2022
Publication statusPublished - 2022


  • C-terminal pro-vasopressin
  • Copeptin
  • heart failure
  • meta-analysis
  • predictor
  • systematic review

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