TY - JOUR
T1 - Safety of Thiopurine Use in Paediatric Gastrointestinal Disease
AU - Miele, Erasmo
AU - Benninga, Marc A.
AU - Broekaert, Ilse
AU - Dolinsek, Jernej
AU - Mas, Emmanuel
AU - Orel, Rok
AU - Pienar, Corina
AU - Ribes-Koninckx, Carmen
AU - Thomassen, Rut A.
AU - Thomson, Mike
AU - Tzivinikos, Christos
AU - Thapar, Nikhil
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Thiopurines, alone or in combination with other agents, have a pivotal role in the treatment of specific gastrointestinal and hepatological disorders. In inflammatory bowel disease and autoimmune hepatitis thiopurines have proven their value as steroid sparing agents for the maintenance of remission and may be considered for preventing postoperative Crohn disease recurrence where there is moderate risk of this occurring. Their use with infliximab therapy reduces antibody formation and increases biologic drug levels. The routine clinical use of thiopurines has, however, been questioned due to a number of potential adverse effects. The aim of this article is to provide information regarding the use, and in particular, safety of these agents in clinical practice in the light of such potentially severe, albeit rare, effects.
AB - Thiopurines, alone or in combination with other agents, have a pivotal role in the treatment of specific gastrointestinal and hepatological disorders. In inflammatory bowel disease and autoimmune hepatitis thiopurines have proven their value as steroid sparing agents for the maintenance of remission and may be considered for preventing postoperative Crohn disease recurrence where there is moderate risk of this occurring. Their use with infliximab therapy reduces antibody formation and increases biologic drug levels. The routine clinical use of thiopurines has, however, been questioned due to a number of potential adverse effects. The aim of this article is to provide information regarding the use, and in particular, safety of these agents in clinical practice in the light of such potentially severe, albeit rare, effects.
UR - http://www.scopus.com/inward/record.url?scp=85089126662&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/MPG.0000000000002802
DO - https://doi.org/10.1097/MPG.0000000000002802
M3 - Article
C2 - 32520827
SN - 0277-2116
VL - 71
SP - 156
EP - 162
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 2
ER -