TY - JOUR
T1 - Salivary peptide histatin 1 mediated cell adhesion
T2 - a possible role in mesenchymal-epithelial transition and in pathologies
AU - Van Dijk, I.A.
AU - Veerman, E.C.I.
AU - Reits, E.A.J.
AU - Bolscher, J.G.M.
AU - Stap, J.
PY - 2018
Y1 - 2018
N2 - Histatins are histidine-rich peptides present in the saliva of humans and higher primates and have been implicated in the protection of the oral cavity. Histatin 1 is one of the most abundant histatins and recent reports show that it has a stimulating effect on cellular adherence, thereby suggesting a role in maintaining the quality of the epithelial barrier and stimulating mesenchymal-to-epithelial transition. Here we summarize these findings and discuss them in the context of previous reports. The recent findings also provide new insights in the physiological functions of histatin 1, which are discussed here. Furthermore, we put forward a possible role of histatin 1 in various pathologies and its potential function in clinical applications.
AB - Histatins are histidine-rich peptides present in the saliva of humans and higher primates and have been implicated in the protection of the oral cavity. Histatin 1 is one of the most abundant histatins and recent reports show that it has a stimulating effect on cellular adherence, thereby suggesting a role in maintaining the quality of the epithelial barrier and stimulating mesenchymal-to-epithelial transition. Here we summarize these findings and discuss them in the context of previous reports. The recent findings also provide new insights in the physiological functions of histatin 1, which are discussed here. Furthermore, we put forward a possible role of histatin 1 in various pathologies and its potential function in clinical applications.
KW - angiogenesis
KW - cell adhesion
KW - cell migration
KW - epithelial barrier
KW - mesenchymal-epithelial transition
KW - wound closure
UR - http://www.scopus.com/inward/record.url?scp=85053109907&partnerID=8YFLogxK
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053109907&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30138105
U2 - https://doi.org/10.1515/hsz-2018-0246
DO - https://doi.org/10.1515/hsz-2018-0246
M3 - Review article
C2 - 30138105
SN - 1431-6730
VL - 399
SP - 1409
EP - 1419
JO - Biological chemistry
JF - Biological chemistry
IS - 12
ER -