Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation

Juan Anguita, Nandhini Ramamoorthi, Joppe W. R. Hovius, Subrata Das, Venetta Thomas, Rafal Persinski, Dietrich Conze, Philip W. Askenase, Mercedes Rincón, Fred S. Kantor, Erol Fikrig

Research output: Contribution to journalArticle*Academicpeer-review

Abstract

Tick saliva has pleiotropic properties that facilitate persistence of the arthropod upon the host. We now describe a feeding-inducible protein in Ixodes scapularis saliva, Salp15, that inhibits CD4(+) T cell activation. The mechanism involves the repression of calcium fluxes triggered by TCR ligation and results in lower production of interleukin-2. Salp15 also inhibits the development of CD4(+) T cell-mediated immune responses in vivo, demonstrating the functional importance of this protein. Salp15 provides a molecular basis for understanding the immunosuppressive activity of I. scapularis saliva and vector-host interactions
Original languageEnglish
Pages (from-to)849-859
JournalImmunity
Volume16
Issue number6
DOIs
Publication statusPublished - 2002

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