Seasonal coronavirus protective immunity is short-lasting

Arthur W. D. Edridge, Joanna Kaczorowska, Alexis C. R. Hoste, Margreet Bakker, Michelle Klein, Katherine Loens, Maarten F. Jebbink, Amy Matser, Cormac M. Kinsella, Paloma Rueda, Margareta Ieven, Herman Goossens, Maria Prins, Patricia Sastre, Martin Deijs, Lia van der Hoek

Research output: Contribution to JournalArticleAcademicpeer-review

350 Citations (Scopus)


A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is the duration of acquired immunity. Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.
Original languageEnglish
Pages (from-to)1691-1693
Number of pages3
JournalNature Medicine
Issue number11
Early online date2020
Publication statusPublished - Nov 2020

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