TY - JOUR
T1 - Selecting magnetic resonance imaging (MRI) outcome measures for juvenile idiopathic arthritis (JIA) clinical trials
T2 - first report of the MRI in JIA special interest group
AU - Hemke, Robert
AU - Doria, Andrea S
AU - Tzaribachev, Nikolay
AU - Maas, Mario
AU - van der Heijde, Désirée M F M
AU - van Rossum, Marion A J
PY - 2014/2
Y1 - 2014/2
N2 - Recent advances in magnetic resonance imaging (MRI) techniques have substantially improved the evaluation of joint pathologies in juvenile idiopathic arthritis (JIA). Because of the current availability of highly effective antirheumatic therapies and the unique and useful features of MRI, there is a growing need for an accurate and reproducible MRI assessment scoring system for JIA, such as the rheumatoid arthritis MRI Scoring (RAMRIS) for patients with rheumatoid arthritis (RA). To effectively evaluate the efficacy of treatment in clinical research trials, we need to develop and validate scoring methods to accurately measure joint outcomes, standardize imaging protocols for data acquisition and interpretation, and create imaging atlases to differentiate physiologic and pathologic joint findings in childhood and adolescence. Such a standardized, validated, JIA-MRI scoring method could be used as an outcome measure in clinical trials.
AB - Recent advances in magnetic resonance imaging (MRI) techniques have substantially improved the evaluation of joint pathologies in juvenile idiopathic arthritis (JIA). Because of the current availability of highly effective antirheumatic therapies and the unique and useful features of MRI, there is a growing need for an accurate and reproducible MRI assessment scoring system for JIA, such as the rheumatoid arthritis MRI Scoring (RAMRIS) for patients with rheumatoid arthritis (RA). To effectively evaluate the efficacy of treatment in clinical research trials, we need to develop and validate scoring methods to accurately measure joint outcomes, standardize imaging protocols for data acquisition and interpretation, and create imaging atlases to differentiate physiologic and pathologic joint findings in childhood and adolescence. Such a standardized, validated, JIA-MRI scoring method could be used as an outcome measure in clinical trials.
KW - Antirheumatic Agents/therapeutic use
KW - Arthritis, Juvenile/drug therapy
KW - Clinical Trials as Topic
KW - Humans
KW - Joints/pathology
KW - Magnetic Resonance Imaging/methods
KW - Outcome Assessment, Health Care
KW - Synovitis/drug therapy
U2 - https://doi.org/10.3899/jrheum.131081
DO - https://doi.org/10.3899/jrheum.131081
M3 - Article
C2 - 24187109
SN - 0315-162X
VL - 41
SP - 354
EP - 358
JO - The Journal of rheumatology
JF - The Journal of rheumatology
IS - 2
ER -