Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

B. M. de Jong; J. M. Ruijter; T. P. van der Woude; M. Mirmiran; E. A. van Royen

Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

B. M. de Jong, J. M. Ruijter, T. P. van der Woude, M. Mirmiran, E. A. van Royen

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Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings

Original language	English
Pages (from-to)	753-757
Journal	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
Volume	16
Issue number	8
Publication status	Published - 1989

Cite this

@article{57565947c0f049319927bfa92ce87ea6,

title = "Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo",

abstract = "The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings",

author = "{de Jong}, {B. M.} and Ruijter, {J. M.} and {van der Woude}, {T. P.} and M. Mirmiran and {van Royen}, {E. A.}",

year = "1989",

language = "English",

volume = "16",

pages = "753--757",

journal = "International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology",

issn = "0883-2897",

publisher = "Elsevier BV",

number = "8",

}

Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo. / de Jong, B. M.; Ruijter, J. M.; van der Woude, T. P. et al.
In: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, Vol. 16, No. 8, 1989, p. 753-757.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Serotonergic denervation does not reduce brain uptake of n-isopropyl-p-[123I]iodoamphetamine in vivo

AU - de Jong, B. M.

AU - Ruijter, J. M.

AU - van der Woude, T. P.

AU - Mirmiran, M.

AU - van Royen, E. A.

PY - 1989

Y1 - 1989

N2 - The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings

AB - The relation between brain uptake of radiolabeled n-isopropyl-p-iodoamphetamine [( 123I]IMP) and serotonin re-uptake sites was studied in vivo by lesioning serotonergic nerve endings. The reduction of brain serotonin demonstrated the effectiveness of the procedure. Accumulation of radioactivity/g brain tissue was higher in the lesioned than in the sham-operated rats. This was explained by the loss of body weight of the lesioned animals, allowing an increased distribution to the brain. These results demonstrate that the in vivo distribution and binding of [123I]IMP in the brain is not limited to the specific serotonin re-uptake sites on nerve endings

M3 - Article

C2 - 2621111

SN - 0883-2897

VL - 16

SP - 753

EP - 757

JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

IS - 8

ER -