TY - JOUR
T1 - Serum hepcidin in infants born after 32 to 37 wk of gestational age
AU - Uijterschout, Lieke
AU - Domellöf, Magnus
AU - Berglund, Staffan K.
AU - Abbink, Micky
AU - Vos, Paul
AU - Rövekamp, Lyanne
AU - Boersma, Bart
AU - Lagerqvist, Carina
AU - Hudig, Cisca
AU - van Goudoever, Johannes B.
AU - Brus, Frank
AU - Domellof, Magnus
AU - Rovekamp, L.
N1 - M1 - 4 ISI Document Delivery No.: DJ7GR Times Cited: 0 Cited Reference Count: 33 Uijterschout, Lieke Domellof, Magnus Berglund, Staffan K. Abbink, Micky Vos, Paul Rovekamp, Lyanne Boersma, Bart Lagerqvist, Carina Hudig, Cisca van Goudoever, Johannes B. Brus, Frank Nutricia Research Foundation Hepcidin analyses were financed by Nutricia Research Foundation. Nutricia had no role in the study design, analysis, or interpretation of the data; writing the manuscript; or the decision to submit the paper for publication. 0 1 2 NATURE PUBLISHING GROUP NEW YORK PEDIATR RES
PY - 2016
Y1 - 2016
N2 - Preterm infants are at risk of iron deficiency (ID). Hepcidin has been suggested as a good additional indicator of ID in preterm infants, next to ferritin. In a prospective observational study, we analyzed serum hepcidin in 111 infants born after 32+0 to 36+6 wk gestational age during the first 4 mo of life. Hepcidin concentrations decreased during the first 4 mo of life, and concentrations were lower in infants with ID compared to those without ID. Infants who developed ID at the age of 4 mo had already significantly lower levels of hepcidin at 1.5 mo of age, while ferritin was already significantly lower at the age of 1 wk. Hepcidin concentrations of late preterm infants decrease during the first 4 mo of life. This decrease, which parallels a decrease of ferritin concentration, we interpret as a physiological response, aiming to increase iron availability. Hepcidin concentrations are lower in infants with ID compared with those without ID, with a notable change already observed at 1.5 mo of age. Hepcidin can be used as an early marker of ID, although an additive value of hepcidin over ferritin in the diagnosis of ID is not present
AB - Preterm infants are at risk of iron deficiency (ID). Hepcidin has been suggested as a good additional indicator of ID in preterm infants, next to ferritin. In a prospective observational study, we analyzed serum hepcidin in 111 infants born after 32+0 to 36+6 wk gestational age during the first 4 mo of life. Hepcidin concentrations decreased during the first 4 mo of life, and concentrations were lower in infants with ID compared to those without ID. Infants who developed ID at the age of 4 mo had already significantly lower levels of hepcidin at 1.5 mo of age, while ferritin was already significantly lower at the age of 1 wk. Hepcidin concentrations of late preterm infants decrease during the first 4 mo of life. This decrease, which parallels a decrease of ferritin concentration, we interpret as a physiological response, aiming to increase iron availability. Hepcidin concentrations are lower in infants with ID compared with those without ID, with a notable change already observed at 1.5 mo of age. Hepcidin can be used as an early marker of ID, although an additive value of hepcidin over ferritin in the diagnosis of ID is not present
U2 - https://doi.org/10.1038/pr.2015.258
DO - https://doi.org/10.1038/pr.2015.258
M3 - Article
C2 - 26672736
SN - 0031-3998
VL - 79
SP - 608
EP - 613
JO - Pediatric Research
JF - Pediatric Research
IS - 4
ER -