TY - JOUR
T1 - Severe Cardiorespiratory and Neurologic Symptoms in a Neonate due to Mepivacaine Intoxication
AU - de Groot-van der Mooren, Maurike
AU - Quint, Sabine
AU - Knobbe, Ingmar
AU - Cronie, Doug
AU - van Weissenbruch, Mirjam
PY - 2019
Y1 - 2019
N2 - Local anesthesia with mepivacaine is used for vaginal deliveries and for minor surgeries of the vagina and perineum as repair of an episiotomy or perineal laceration. Neonatal intoxication caused by local anesthesia with mepivacaine for maternal episiotomy has been rarely reported. We present a case of a term female infant with unexplained cardiorespiratory distress and several neurologic findings, including seizures, one hour after birth. Electrocardiogram showed a second-degree atrioventricular block and a left-bundle branch block. Blood measures in the patient revealed a high mepivacaine level following local anesthesia for maternal episiotomy. Because of the increasing practice of local anesthesia, high awareness for neonatal intoxication and further research in safe elimination therapy in neonates is needed.
AB - Local anesthesia with mepivacaine is used for vaginal deliveries and for minor surgeries of the vagina and perineum as repair of an episiotomy or perineal laceration. Neonatal intoxication caused by local anesthesia with mepivacaine for maternal episiotomy has been rarely reported. We present a case of a term female infant with unexplained cardiorespiratory distress and several neurologic findings, including seizures, one hour after birth. Electrocardiogram showed a second-degree atrioventricular block and a left-bundle branch block. Blood measures in the patient revealed a high mepivacaine level following local anesthesia for maternal episiotomy. Because of the increasing practice of local anesthesia, high awareness for neonatal intoxication and further research in safe elimination therapy in neonates is needed.
U2 - https://doi.org/10.1155/2019/4013564
DO - https://doi.org/10.1155/2019/4013564
M3 - Article
C2 - 31428498
SN - 2090-6803
VL - 2019
JO - Case reports in pediatrics
JF - Case reports in pediatrics
M1 - 4013564
ER -