TY - JOUR
T1 - Short communication
T2 - High prevalence of transmitted antiretroviral drug resistance among newly HIV Type 1 diagnosed adults in mombasa, Kenya
AU - Sigaloff, Kim C.E.
AU - Mandaliya, Kishor
AU - Hamers, Raph L.
AU - Otieno, Francis
AU - Jao, Irene M.
AU - Lyagoba, Frederick
AU - Magambo, Brian
AU - Kapaata, Anne
AU - Ndembi, Nicaise
AU - Rinke De Wit, Tobias F.
PY - 2012/9/1
Y1 - 2012/9/1
N2 - In view of the recent antiretroviral therapy (ART) scale-up in Kenya, surveillance of transmitted HIV drug resistance (TDR) is important. A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive adults in Mombasa, Kenya. Surveillance drug resistance mutations (SDRMs) were identified according to the 2009 WHO list. HIV-1 subtypes were determined using REGA and SCUEAL subtyping tools. Genotypic test results were obtained for 68 of 81 participants, and SDRMs were identified in 9 samples. Resistance to nonnucleoside reverse transcriptase inhibitors (K103N) occurred in five participants, yielding a TDR prevalence of 7.4% (95% confidence interval 2.4-16.3%). Frequencies of HIV-1 subtypes were A (70.6%), C (5.9%), D (2.9%), and unique recombinant forms (20.6%). The TDR prevalence found in this survey is higher than previously reported in different regions in Kenya. These findings justify increased vigilance with respect to TDR surveillance in African regions where ART programs are scaled-up in order to inform treatment guidelines.
AB - In view of the recent antiretroviral therapy (ART) scale-up in Kenya, surveillance of transmitted HIV drug resistance (TDR) is important. A cross-sectional survey was conducted among newly HIV-1 diagnosed, antiretroviral-naive adults in Mombasa, Kenya. Surveillance drug resistance mutations (SDRMs) were identified according to the 2009 WHO list. HIV-1 subtypes were determined using REGA and SCUEAL subtyping tools. Genotypic test results were obtained for 68 of 81 participants, and SDRMs were identified in 9 samples. Resistance to nonnucleoside reverse transcriptase inhibitors (K103N) occurred in five participants, yielding a TDR prevalence of 7.4% (95% confidence interval 2.4-16.3%). Frequencies of HIV-1 subtypes were A (70.6%), C (5.9%), D (2.9%), and unique recombinant forms (20.6%). The TDR prevalence found in this survey is higher than previously reported in different regions in Kenya. These findings justify increased vigilance with respect to TDR surveillance in African regions where ART programs are scaled-up in order to inform treatment guidelines.
UR - http://www.scopus.com/inward/record.url?scp=84860372956&partnerID=8YFLogxK
U2 - https://doi.org/10.1089/aid.2011.0348
DO - https://doi.org/10.1089/aid.2011.0348
M3 - Article
C2 - 22149307
SN - 0889-2229
VL - 28
SP - 833
EP - 837
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 9
ER -