TY - JOUR
T1 - Sickle cell nephropathy
T2 - insights into the pediatric population
AU - Adebayo, Oyindamola C.
AU - van den Heuvel, Lambertus P.
AU - Olowu, Wasiu A.
AU - Levtchenko, Elena N.
AU - Labarque, Veerle
PY - 2022/6/1
Y1 - 2022/6/1
N2 - The life expectancy of individuals with sickle cell disease has increased over the years, majorly due to an overall improvement in diagnosis and medical care. Nevertheless, this improved longevity has resulted in an increased prevalence of chronic complications such as sickle cell nephropathy (SCN), which poses a challenge to the medical care of the patient, shortening the lifespan of patients by 20–30 years. Clinical presentation of SCN is age-dependent, with kidney dysfunction slowly beginning to develop from childhood, progressing to chronic kidney disease and kidney failure during the third and fourth decades of life. This review explores the epidemiology, pathology, pathophysiology, clinical presentation, and management of SCN by focusing on the pediatric population. It also discusses the factors that can modify SCN susceptibility.
AB - The life expectancy of individuals with sickle cell disease has increased over the years, majorly due to an overall improvement in diagnosis and medical care. Nevertheless, this improved longevity has resulted in an increased prevalence of chronic complications such as sickle cell nephropathy (SCN), which poses a challenge to the medical care of the patient, shortening the lifespan of patients by 20–30 years. Clinical presentation of SCN is age-dependent, with kidney dysfunction slowly beginning to develop from childhood, progressing to chronic kidney disease and kidney failure during the third and fourth decades of life. This review explores the epidemiology, pathology, pathophysiology, clinical presentation, and management of SCN by focusing on the pediatric population. It also discusses the factors that can modify SCN susceptibility.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85107302930&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/34050806
U2 - https://doi.org/10.1007/s00467-021-05126-4
DO - https://doi.org/10.1007/s00467-021-05126-4
M3 - Review article
C2 - 34050806
SN - 0931-041X
VL - 37
SP - 1231
EP - 1243
JO - Pediatric nephrology (Berlin, Germany)
JF - Pediatric nephrology (Berlin, Germany)
IS - 6
ER -