Silent ischaemia in familial hypercholesterolemia

Olivier S. Descamps; Antoine de Meester; Paul Cheron; John J. Kastelein; Francis R. Heller

doi:https://doi.org/10.1016/S1567-5688(03)00024-2

Silent ischaemia in familial hypercholesterolemia

Olivier S. Descamps, Antoine de Meester, Paul Cheron, John J. Kastelein, Francis R. Heller

Research output: Contribution to journal › Comment/Letter to the editor › Academic

12 Citations (Scopus)

Abstract

In a cohort of 66 FH-men (age 25-55) prospectively recruited during a 2-years period, we estimated the incidence of coronary heart disease to 52% (N = 34). Thirt-two percent (N = 21) had earlier history of symptomatic ischaemic disease whereas 20% (N = 13) had significant ST/T changes during exercise stress test. Amongst the 8 patients with positive exercise stress test who underwent coronary angiography, six had severe coronary artery disease. Because of the severity of the stenotic lesions, 4 of these 6 patients underwent coronary angioplasty or surgical bypass. We concluded that a great proportion of FH men suffered from myocardial ischaemia, either asymptomatic or symptomatic, and that even the silent form is associated with severe coronary stenosis. This advocates to systematically perform exercise testing in asymptomatic FH men after age 25. (C) 2003 Elsevier Ireland Ltd. All rights reserved

Original language	English
Pages (from-to)	7-8
Journal	Atherosclerosis. Supplements
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/S1567-5688(03)00024-2
Publication status	Published - 2003

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https://doi.org/10.1016/S1567-5688(03)00024-2

Cite this

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title = "Silent ischaemia in familial hypercholesterolemia",

abstract = "In a cohort of 66 FH-men (age 25-55) prospectively recruited during a 2-years period, we estimated the incidence of coronary heart disease to 52% (N = 34). Thirt-two percent (N = 21) had earlier history of symptomatic ischaemic disease whereas 20% (N = 13) had significant ST/T changes during exercise stress test. Amongst the 8 patients with positive exercise stress test who underwent coronary angiography, six had severe coronary artery disease. Because of the severity of the stenotic lesions, 4 of these 6 patients underwent coronary angioplasty or surgical bypass. We concluded that a great proportion of FH men suffered from myocardial ischaemia, either asymptomatic or symptomatic, and that even the silent form is associated with severe coronary stenosis. This advocates to systematically perform exercise testing in asymptomatic FH men after age 25. (C) 2003 Elsevier Ireland Ltd. All rights reserved",

author = "Descamps, {Olivier S.} and {de Meester}, Antoine and Paul Cheron and Kastelein, {John J.} and Heller, {Francis R.}",

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TY - JOUR

T1 - Silent ischaemia in familial hypercholesterolemia

AU - Descamps, Olivier S.

AU - de Meester, Antoine

AU - Cheron, Paul

AU - Kastelein, John J.

AU - Heller, Francis R.

PY - 2003

Y1 - 2003

N2 - In a cohort of 66 FH-men (age 25-55) prospectively recruited during a 2-years period, we estimated the incidence of coronary heart disease to 52% (N = 34). Thirt-two percent (N = 21) had earlier history of symptomatic ischaemic disease whereas 20% (N = 13) had significant ST/T changes during exercise stress test. Amongst the 8 patients with positive exercise stress test who underwent coronary angiography, six had severe coronary artery disease. Because of the severity of the stenotic lesions, 4 of these 6 patients underwent coronary angioplasty or surgical bypass. We concluded that a great proportion of FH men suffered from myocardial ischaemia, either asymptomatic or symptomatic, and that even the silent form is associated with severe coronary stenosis. This advocates to systematically perform exercise testing in asymptomatic FH men after age 25. (C) 2003 Elsevier Ireland Ltd. All rights reserved

AB - In a cohort of 66 FH-men (age 25-55) prospectively recruited during a 2-years period, we estimated the incidence of coronary heart disease to 52% (N = 34). Thirt-two percent (N = 21) had earlier history of symptomatic ischaemic disease whereas 20% (N = 13) had significant ST/T changes during exercise stress test. Amongst the 8 patients with positive exercise stress test who underwent coronary angiography, six had severe coronary artery disease. Because of the severity of the stenotic lesions, 4 of these 6 patients underwent coronary angioplasty or surgical bypass. We concluded that a great proportion of FH men suffered from myocardial ischaemia, either asymptomatic or symptomatic, and that even the silent form is associated with severe coronary stenosis. This advocates to systematically perform exercise testing in asymptomatic FH men after age 25. (C) 2003 Elsevier Ireland Ltd. All rights reserved

U2 - https://doi.org/10.1016/S1567-5688(03)00024-2

DO - https://doi.org/10.1016/S1567-5688(03)00024-2

M3 - Comment/Letter to the editor

C2 - 14615273

VL - 4

SP - 7

EP - 8

JO - Atherosclerosis. Supplements

JF - Atherosclerosis. Supplements

SN - 1567-5688

IS - 3

ER -