Simultaneous imaging of ultrasound attenuation, speed of sound and optical absorption in a photoacoustic setup

Rene G.H. Willemink, Srirang Manohar, Jithin Jose, Kees Slump, Ferdi Van Der Heijden, Ton G. Van Leeuwen

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)


Photoacoustic imaging is a relatively new medical imaging modality. In principle it can be used to image the optical absorption distribution of an object by measurements of optically induced acoustic signals. Recently we have developed a modified photoacoustic measurement system which can be used to simultaneously image the ultrasound propagation parameters as well. By proper placement of a passive element we obtain isolated measurements of the object's ultrasound propagation parameters, independent of the optical absorption inside the object. This passive element acts as a photoacoustic source and measurements are obtained by allowing the generated ultrasound signal to propagate through the object. Images of the ultrasound propagation parameters, being the attenuation and speed of sound, can then be reconstructed by inversion of a measurement model. This measurement model relates the projections non-linearly to the unknown images, due to ray refraction effects. After estimating the speed of sound and attenuation distribution, the optical absorption distribution is reconstructed. In this reconstruction problem we take into account the previously estimated speed of sound distribution. So far, the reconstruction algorithms have been tested using computer simulations. The method has been compared with existing algorithms and good results have been obtained.

Original languageEnglish
Title of host publicationMedical Imaging 2009
Subtitle of host publicationUltrasonic Imaging and Signal Processing
Publication statusPublished - 2009
EventMedical Imaging 2009: Ultrasonic Imaging and Signal Processing - Lake Buena Vista, FL, United States
Duration: 8 Feb 20099 Feb 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE


ConferenceMedical Imaging 2009: Ultrasonic Imaging and Signal Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Inhomogeneous speed of sound
  • Photoacoustic imaging
  • Ray refraction correction
  • Ultrasound tomography

Cite this