TY - JOUR
T1 - Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder
AU - Carvalho, Carolina M.
AU - Coimbra, Bruno M.
AU - Ota, Vanessa K.
AU - Mello, Marcelo F.
AU - Belangero, Sintia I.
N1 - Funding Information: This work was supported by a research grant from the Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo (Vidi grant: FAPESP 2014/12559-5; FAPESP 2014/07280-1) Publisher Copyright: © 2017 Wiley Periodicals, Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/10
Y1 - 2017/10
N2 - Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is strongly correlated with this disorder. One hypothesis is that HPA axis dysfunction may precede the traumatic event, suggesting that genes expressed in the HPA axis may be involved in the development of PTSD. This article reviews molecular genetic studies related to PTSD collected through a literature search performed in PubMed, MEDLINE, ScienceDirect, and Scientific Electronic Library Online (SciELO). The results of these studies suggest that several polymorphisms in the HPA axis genes, including FKBP5, NR3C1, CRHR1, and CRHR2, may be risk factors for PTSD development or may be associated with the severity of PTSD symptoms.
AB - Posttraumatic stress disorder (PTSD) is a common psychiatric disorder. The etiology of PTSD is multifactorial, depending on many environmental and genetic risk factors, and the exposure to life or physical integrity-threatening events. Several studies have shown significant correlations of many neurobiological findings with PTSD. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is strongly correlated with this disorder. One hypothesis is that HPA axis dysfunction may precede the traumatic event, suggesting that genes expressed in the HPA axis may be involved in the development of PTSD. This article reviews molecular genetic studies related to PTSD collected through a literature search performed in PubMed, MEDLINE, ScienceDirect, and Scientific Electronic Library Online (SciELO). The results of these studies suggest that several polymorphisms in the HPA axis genes, including FKBP5, NR3C1, CRHR1, and CRHR2, may be risk factors for PTSD development or may be associated with the severity of PTSD symptoms.
KW - HPA axis
KW - PTSD
KW - gene
KW - polymorphisms
KW - trauma
UR - http://www.scopus.com/inward/record.url?scp=85022013008&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/ajmg.b.32564
DO - https://doi.org/10.1002/ajmg.b.32564
M3 - Review article
C2 - 28686326
SN - 1552-4841
VL - 174
SP - 671
EP - 682
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 7
ER -