Sirtuins as regulators of metabolism and healthspan

Riekelt H. Houtkooper, Eija Pirinen, Johan Auwerx

    Research output: Contribution to journalReview articleAcademicpeer-review

    1505 Citations (Scopus)

    Abstract

    Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan
    Original languageEnglish
    Pages (from-to)225-238
    JournalNature reviews. Molecular cell biology
    Volume13
    Issue number4
    DOIs
    Publication statusPublished - 2012

    Cite this