TY - JOUR
T1 - Sirtuins as regulators of metabolism and healthspan
AU - Houtkooper, Riekelt H.
AU - Pirinen, Eija
AU - Auwerx, Johan
PY - 2012
Y1 - 2012
N2 - Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan
AB - Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan
U2 - https://doi.org/10.1038/nrm3293
DO - https://doi.org/10.1038/nrm3293
M3 - Review article
C2 - 22395773
SN - 1471-0072
VL - 13
SP - 225
EP - 238
JO - Nature reviews. Molecular cell biology
JF - Nature reviews. Molecular cell biology
IS - 4
ER -