Sirtuins as regulators of metabolism and healthspan

Riekelt H. Houtkooper, Eija Pirinen, Johan Auwerx

Research output: Contribution to journalReview articleAcademicpeer-review


Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan
Original languageEnglish
Pages (from-to)225-238
JournalNature Reviews. Molecular Cell Biology
Issue number4
Publication statusPublished - 2012

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