TY - JOUR
T1 - Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia
T2 - A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia
AU - Logue, Mark W.
AU - van Rooij, Sanne J. H.
AU - Dennis, Emily L.
AU - Davis, Sarah L.
AU - Hayes, Jasmeet P.
AU - Stevens, Jennifer S.
AU - Densmore, Maria
AU - Haswell, Courtney C.
AU - Ipser, Jonathan
AU - Koch, Saskia B. J.
AU - Korgaonkar, Mayuresh
AU - Lebois, Lauren A. M.
AU - Peverill, Matthew
AU - Baker, Justin T.
AU - Boedhoe, Premika S. W.
AU - Frijling, Jessie L.
AU - Gruber, Staci A.
AU - Harpaz-Rotem, Ilan
AU - Jahanshad, Neda
AU - Koopowitz, Sheri
AU - Levy, Ifat
AU - Nawijn, Laura
AU - O'Connor, Lauren
AU - Olff, Miranda
AU - Salat, David H.
AU - Sheridan, Margaret A.
AU - Spielberg, Jeffrey M.
AU - van Zuiden, Mirjam
AU - Winternitz, Sherry R.
AU - Wolff, Jonathan D.
AU - Wolf, Erika J.
AU - Wang, Xin
AU - Wrocklage, Kristen
AU - Abdallah, Chadi G.
AU - Bryant, Richard A.
AU - Geuze, Elbert
AU - Jovanovic, Tanja
AU - Kaufman, Milissa L.
AU - King, Anthony P.
AU - Krystal, John H.
AU - Lagopoulos, Jim
AU - Bennett, Maxwell
AU - Lanius, Ruth
AU - Liberzon, Israel
AU - McGlinchey, Regina E.
AU - McLaughlin, Katie A.
AU - Milberg, William P.
AU - Miller, Mark W.
AU - Ressler, Kerry J.
AU - Veltman, Dick J.
AU - Stein, Dan J.
AU - Thomaes, Kathleen
AU - Thompson, Paul M.
AU - Morey, Rajendra A.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. METHODS: We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. RESULTS: In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = 20.17, p =.00054), and smaller amygdalae (d = 20.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). CONCLUSIONS: Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma
AB - BACKGROUND: Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)-Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group. METHODS: We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and quality-control pipeline established by the ENIGMA consortium. RESULTS: In a meta-analysis of all samples, we found significantly smaller hippocampi in subjects with current PTSD compared with trauma-exposed control subjects (Cohen's d = 20.17, p =.00054), and smaller amygdalae (d = 20.11, p =.025), although the amygdala finding did not survive a significance level that was Bonferroni corrected for multiple subcortical region comparisons (p <.0063). CONCLUSIONS: Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma
KW - Amygdala
KW - Childhood trauma
KW - Gender differences
KW - Hippocampus
KW - PTSD
KW - Structural MRI
UR - http://www.scopus.com/inward/record.url?scp=85034845116&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.biopsych.2017.09.006
DO - https://doi.org/10.1016/j.biopsych.2017.09.006
M3 - Article
C2 - 29217296
SN - 0006-3223
VL - 83
SP - 244
EP - 253
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 3
ER -