TY - JOUR
T1 - Smoking, obesity, and disability worsening in PPMS: an analysis of the INFORMS original trial dataset
T2 - an analysis of the INFORMS original trial dataset
AU - Koch, Marcus W.
AU - Mostert, Jop
AU - Repovic, Pavle
AU - Bowen, James D.
AU - Strijbis, Eva
AU - Uitdehaag, Bernard
AU - Cutter, Gary
N1 - Publisher Copyright: © 2021, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/3
Y1 - 2022/3
N2 - Background: Smoking and obesity are recognized modifiable risk factors associated with a higher MS incidence, but their impact on physical and cognitive disability worsening is less clear. Objective: To investigate the impact of smoking and obesity on disability worsening in primary progressive MS (PPMS). Methods: We used data from INFORMS (clinicaltrials.gov identifier: NCT00731692), a large randomized-controlled trial in PPMS to compare significant worsening on the EDSS, T25FW, NHPT, and PASAT between smokers and non-smokers, and between BMI groups, at 12, 24, and 33 months of follow-up. We investigated the association of smoking and BMI at screening and the risk of disability worsening with logistic regression models. Results: Smokers had significantly higher EDSS scores throughout the trial. EDSS was not significantly different between BMI categories. No other outcome measure was significantly different between smokers and non-smokers and between BMI categories throughout the trial. Neither smoking status nor BMI were associated with significant worsening on any outcome measure at any time point during follow-up. Conclusion: Despite the known effects on MS incidence, smoking and BMI were not associated with the risk of physical and cognitive disability worsening over 3 years in this well-characterized PPMS trial cohort.
AB - Background: Smoking and obesity are recognized modifiable risk factors associated with a higher MS incidence, but their impact on physical and cognitive disability worsening is less clear. Objective: To investigate the impact of smoking and obesity on disability worsening in primary progressive MS (PPMS). Methods: We used data from INFORMS (clinicaltrials.gov identifier: NCT00731692), a large randomized-controlled trial in PPMS to compare significant worsening on the EDSS, T25FW, NHPT, and PASAT between smokers and non-smokers, and between BMI groups, at 12, 24, and 33 months of follow-up. We investigated the association of smoking and BMI at screening and the risk of disability worsening with logistic regression models. Results: Smokers had significantly higher EDSS scores throughout the trial. EDSS was not significantly different between BMI categories. No other outcome measure was significantly different between smokers and non-smokers and between BMI categories throughout the trial. Neither smoking status nor BMI were associated with significant worsening on any outcome measure at any time point during follow-up. Conclusion: Despite the known effects on MS incidence, smoking and BMI were not associated with the risk of physical and cognitive disability worsening over 3 years in this well-characterized PPMS trial cohort.
KW - Body mass index
KW - Primary progressive multiple sclerosis
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=85112406110&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s00415-021-10750-z
DO - https://doi.org/10.1007/s00415-021-10750-z
M3 - Article
C2 - 34392376
SN - 0340-5354
VL - 269
SP - 1663
EP - 1669
JO - Journal of neurology
JF - Journal of neurology
IS - 3
ER -