Sodium glucose cotransporter 2 inhibition and renal ischemia: implications for future clinical trials

Daniël H. van Raalte, David Z. I. Cherney

Research output: Contribution to journalComment/Letter to the editorAcademic

32 Citations (Scopus)


Sodium glucose cotransporter 2 inhibitors are increasingly being recognized for renal protective effects that are largely independent of hemoglobin A1c–lowering or glucosuria-related endpoints. Accordingly, there is growing interest in potential renal benefits with sodium glucose cotransporter 2 inhibitors in nondiabetic patients to take advantage of natriuresis-mediated effects on blood pressure, proteinuria, and renal function. In this issue of Kidney International, Zhang et al. report renoprotective effects with the sodium glucose cotransporter 2 inhibitor lusogliflozin in an ischemia-reperfusion injury model under nondiabetic conditions, thereby providing important mechanistic insights into the use of these agents in chronic kidney disease.
Original languageEnglish
Pages (from-to)459-462
JournalKidney International
Issue number3
Publication statusPublished - 2018

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