TY - GEN
T1 - Spatial consistency in 3D tract-based clustering statistics
AU - Caan, Matthan
AU - Van Vliet, Lucas
AU - Majoie, Charles
AU - Aukema, Eline
AU - Grimbergen, Kees
AU - Vos, Frans
PY - 2008
Y1 - 2008
N2 - We propose a novel technique for tract-based comparison of DTI-indices between groups, based on a representation that is estimated while matching fiber tracts. The method involves a non-rigid registration based on a joint clustering and matching approach, after which a 3D-atlas of cluster center points is used as a frame of reference for statistics. Patient and control FA-distributions are compared per cluster. Spatial consistency is taken to reflect a significant difference between groups. Accordingly, a non-parametric classification is performed to assess the continuity of pathology over larger tract regions. In a study to infant survivors treated for medulloblastoma with intravenous methotrexate and cranial radiotherapy, significant decreases in FA in major parts of the corpus callosum were found.
AB - We propose a novel technique for tract-based comparison of DTI-indices between groups, based on a representation that is estimated while matching fiber tracts. The method involves a non-rigid registration based on a joint clustering and matching approach, after which a 3D-atlas of cluster center points is used as a frame of reference for statistics. Patient and control FA-distributions are compared per cluster. Spatial consistency is taken to reflect a significant difference between groups. Accordingly, a non-parametric classification is performed to assess the continuity of pathology over larger tract regions. In a study to infant survivors treated for medulloblastoma with intravenous methotrexate and cranial radiotherapy, significant decreases in FA in major parts of the corpus callosum were found.
UR - http://www.scopus.com/inward/record.url?scp=84879305395&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/978-3-540-85988-8_64
DO - https://doi.org/10.1007/978-3-540-85988-8_64
M3 - Conference contribution
C2 - 18979788
SN - 354085987X
SN - 9783540859871
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 535
EP - 542
BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI 2008 - 11th International Conference, Proceedings
T2 - 11th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2008
Y2 - 6 September 2008 through 10 September 2008
ER -