Sperm penetration assay in predicting successful in vitro fertilization. A meta-analysis

B. W. Mol; S. Meijer; S. Yuppa; E. Tan; J. de Vries; P. M. Bossuyt; F. van der Veen

Sperm penetration assay in predicting successful in vitro fertilization. A meta-analysis

B. W. Mol, S. Meijer, S. Yuppa, E. Tan, J. de Vries, P. M. Bossuyt, F. van der Veen

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-embryo transfer

Original language	English
Pages (from-to)	503-508
Journal	Journal of reproductive medicine
Volume	43
Issue number	6
Publication status	Published - 1998

Cite this

@article{1f6cc1bca5384ae2ab2513de3921d0d0,

title = "Sperm penetration assay in predicting successful in vitro fertilization. A meta-analysis",

abstract = "OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-embryo transfer",

author = "Mol, {B. W.} and S. Meijer and S. Yuppa and E. Tan and {de Vries}, J. and Bossuyt, {P. M.} and {van der Veen}, F.",

year = "1998",

language = "English",

volume = "43",

pages = "503--508",

journal = "Journal of reproductive medicine",

issn = "0024-7758",

publisher = "Donna Kessel",

number = "6",

}

TY - JOUR

T1 - Sperm penetration assay in predicting successful in vitro fertilization. A meta-analysis

AU - Mol, B. W.

AU - Meijer, S.

AU - Yuppa, S.

AU - Tan, E.

AU - de Vries, J.

AU - Bossuyt, P. M.

AU - van der Veen, F.

PY - 1998

Y1 - 1998

N2 - OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-embryo transfer

AB - OBJECTIVE: To determine if the performance of the sperm penetration assay (SPA) is useful in predicting successful in vitro fertilization (IVF). METHODS: A meta-analysis was set up to determine the performance of SPA in the prediction of IVF success. We collected data on 647 patients in 24 studies. For each study, a two-by-two table was constructed from the results of SPA and IVF. RESULTS: The sensitivity and specificity of SPA as compared to IVF were heterogeneous. A summary receiver operating characteristics curve could be estimated, showing that the sensitivity of SPA was only 37%, with a specificity of 95%. Subgroup analysis did not explain the lack of homogeneity. CONCLUSION: Since withholding IVF inappropriately has major consequences, performing SPA is insufficient for selecting patients for treatment with IVF-embryo transfer

M3 - Article

C2 - 9653696

SN - 0024-7758

VL - 43

SP - 503

EP - 508

JO - Journal of reproductive medicine

JF - Journal of reproductive medicine

IS - 6

ER -