TY - JOUR
T1 - Standardising definitions for the pre-eclampsia core outcome set: A consensus development study
AU - Duffy, James M. N.
AU - Cairns, Alexandra E.
AU - Magee, Laura A.
AU - von Dadelszen, Peter
AU - van 't Hooft, Janneke
AU - Gale, Chris
AU - Brown, Mark
AU - Chappell, Lucy C.
AU - Grobman, William A.
AU - Fitzpatrick, Ray
AU - Karumanchi, S. Ananth
AU - Lucas, D. Nuala
AU - Mol, Ben
AU - Stark, Michael
AU - Thangaratinam, Shakila
AU - Wilson, Mathew J.
AU - International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE)
AU - Williamson, Paula R.
AU - Ziebland, Sue
AU - McManus, Richard J.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Objectives: To develop consensus definitions for the core outcome set for pre-eclampsia. Study design: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. Results: Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. Conclusions: Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0.
AB - Objectives: To develop consensus definitions for the core outcome set for pre-eclampsia. Study design: Potential definitions for individual core outcomes were identified across four formal definition development initiatives, nine national and international guidelines, 12 Cochrane systematic reviews, and 79 randomised trials. Eighty-six definitions were entered into the consensus development meeting. Ten healthcare professionals and three researchers, including six participants who had experience of conducting research in low- and middle-income countries, participated in the consensus development process. The final core outcome set was approved by an international steering group. Results: Consensus definitions were developed for all core outcomes. When considering stroke, pulmonary oedema, acute kidney injury, raised liver enzymes, low platelets, birth weight, and neonatal seizures, consensus definitions were developed specifically for low- and middle-income countries because of the limited availability of diagnostic interventions including computerised tomography, chest x-ray, laboratory tests, equipment, and electroencephalogram monitoring. Conclusions: Consensus on measurements for the pre-eclampsia core outcome set will help to ensure consistency across future randomised trials and systematic reviews. Such standardization should make research evidence more accessible and facilitate the translation of research into clinical practice. Video abstract can be available at: www.dropbox.com/s/ftrgvrfu0u9glqd/6.%20Standardising%20definitions%20in%20teh%20pre-eclampsia%20core%20outcome%20set%3A%20a%20consensus%20development%20study.mp4?dl=0.
KW - Consensus development study
KW - Core outcome set
KW - Hypertension in pregnancy
KW - Outcome measure
KW - Pre-eclampsia
KW - Randomised controlled trials
UR - http://www.scopus.com/inward/record.url?scp=85087746870&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.preghy.2020.06.005
DO - https://doi.org/10.1016/j.preghy.2020.06.005
M3 - Article
C2 - 32674052
SN - 2210-7789
VL - 21
SP - 208
EP - 217
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
ER -