Sub-millimeter fMRI at 1.5 Tesla: Correlation of high resolution with low resolution measurements

Frank G C Hoogenraad, Mark B M Hofman, Petra J W Pouwels, Jürgen R. Reichenbach, Serge A R B Rombouts, E. Mark Haacke

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Functional magnetic resonance imaging of the visual cortex with an in- plane resolution of 0.4 x 0.4 mm2 was performed using a simple visual stimulus resulting in clear maps of activation. A collapsing filter was used to compare these high-resolution images with low-resolution images collected during the same session. A good correspondence between the high- and low- resolution functional maps was found with respect to the center of localization of activation. However, only 20% of the size of activated areas in the low-resolution experiment was observed at high resolution. Which was partly caused by the difference in signal-to-noise ratio. The high-resolution images produce signal changes much higher than the low-resolution images due to reduced partial volume effects. Additionally, the high-resolution functional maps were compared with detailed anatomical and venous information. The activated areas were predominantly observed at venous vessels within the sulci with a diameter on the order of the pixel size.

Original languageEnglish
Pages (from-to)475-482
Number of pages8
JournalJournal of magnetic resonance imaging
Issue number3
Publication statusPublished - 1 Mar 1999


  • Filtering
  • High-resolution
  • MRI
  • Venography
  • Visual cortex
  • fMRI

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