Subsequent Malignant Neoplasms in Retinoblastoma Survivors

Armida W M Fabius; Milo van Hoefen Wijsard; Flora E van Leeuwen; Annette C Moll

doi:https://doi.org/10.3390/cancers13061200

Subsequent Malignant Neoplasms in Retinoblastoma Survivors

Armida W M Fabius, Milo van Hoefen Wijsard, Flora E van Leeuwen, Annette C Moll

Research output: Contribution to journal › Review article › Academic › peer-review

8 Citations (Scopus)

Abstract

Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.

Original language	English
Article number	1200
Pages (from-to)	1-18
Number of pages	18
Journal	Cancers
Volume	13
Issue number	6
DOIs	https://doi.org/10.3390/cancers13061200
Publication status	Published - 2 Mar 2021

Keywords

Heritable Rb
Long‐term surveillance
Retinoblastoma
Second primary malignancies
Subsequent malignant neoplasms
Trilateral Rb

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https://doi.org/10.3390/cancers13061200

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title = "Subsequent Malignant Neoplasms in Retinoblastoma Survivors",

abstract = "Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.",

keywords = "Heritable Rb, Long‐term surveillance, Retinoblastoma, Second primary malignancies, Subsequent malignant neoplasms, Trilateral Rb",

author = "Fabius, {Armida W M} and {van Hoefen Wijsard}, Milo and {van Leeuwen}, {Flora E} and Moll, {Annette C}",

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doi = "https://doi.org/10.3390/cancers13061200",

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T1 - Subsequent Malignant Neoplasms in Retinoblastoma Survivors

AU - Fabius, Armida W M

AU - van Hoefen Wijsard, Milo

AU - van Leeuwen, Flora E

AU - Moll, Annette C

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.

AB - Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.

KW - Heritable Rb

KW - Long‐term surveillance

KW - Retinoblastoma

KW - Second primary malignancies

KW - Subsequent malignant neoplasms

KW - Trilateral Rb

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U2 - https://doi.org/10.3390/cancers13061200

DO - https://doi.org/10.3390/cancers13061200

M3 - Review article

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JO - Cancers

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Subsequent Malignant Neoplasms in Retinoblastoma Survivors

Abstract

Keywords

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