Surrogate markers of antiangiogenic therapies

Epie Boven, Martijn R. Meijerink, Laura Vroling, Astrid A.M. Van Der Veldt

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

The development of antiangiogenic compounds for the treatment of cancer has indicated a need for new clinical tools to evaluate their efficacy, to assess the optimal dose with minimal side-effects and to early select patients who might benefit from antiangiogenic therapies. The use of so-called surrogate biomarkers of angiogenesis and antiangiogenic drug activity in the clinic does not yet belong to the standard of care. Most research has been dedicated towards introduction and refining of imaging techniques, the detection of circulating angiogenic factors and/or related molecules, and characterization and measurement of circulating endothelial cells and early progenitor cells. This chapter will discuss the various possibilities and their limitations illustrated with clinical data on antiangiogenic therapies in cancer patients.

Original languageEnglish
Title of host publicationAngiogenesis and Therapeutic Targets In Cancer
PublisherBentham Science Publishers Ltd
Pages190-208
Number of pages19
ISBN (Print)9781608055739
DOIs
Publication statusPublished - 1 Dec 2010

Keywords

  • Antiangiogenic therapies
  • Cancer patient
  • Efficasy
  • Limitation
  • Surrogate marker

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