Abstract
The application of a biomaterial induces a foreign body reaction. By controlling this reaction, biocompatibility could be improved. We previously demonstrated that impregnation of a biodegradable biomaterial with antibodies against interferon-gamma (IFN-gamma) inhibits the foreign body reaction. In this study we investigate whether systemic administration of the antibody can induce similar reactions. Several parameters are compared between control and anti-IFN-gamma-treated rats: cellular ingrowth; degradation of the biomaterial; ingrowth of macrophage (MO) subsets, T cells, B cells, NK cells, and granulocytes; and expression of the major histocompatibility complex class II (MHC class II) molecule on antigen presenting cells. Treatment with anti-IFN-gamma results in increased cellular ingrowth and biomaterial degradation and a decreased expression of MHC class II. Overall, systemic treatment with anti-IFN-gamma is insufficient to modulate the foreign body reaction. This suggests an alternative mechanism for MO activation besides IFN-gamma. The role of T cells and MO subsets in the foreign body reaction is discussed.
Original language | English |
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Pages (from-to) | 297-304 |
Number of pages | 8 |
Journal | Biomedical materials (Bristol, England) |
Volume | 49 |
Issue number | 3 |
DOIs | |
Publication status | Published - 5 Mar 2000 |
Keywords
- Animals
- Antibodies/administration & dosage
- Biocompatible Materials/toxicity
- Collagen/immunology
- Foreign-Body Reaction/immunology
- Interferon-gamma/antagonists & inhibitors
- Macrophage Activation
- Macrophages/classification
- Male
- Rats
- Sheep
- Skin/immunology