TY - JOUR
T1 - +T Cell Subset Proteomes Supports a Progressive Differentiation Model of Human-Virus-Specific T Cells
AU - van Aalderen, Michiel C.
AU - van den Biggelaar, Maartje
AU - Remmerswaal, Ester B. M.
AU - van Alphen, Floris P. J.
AU - Meijer, Alexander B.
AU - ten Berge, Ineke J. M.
AU - van Lier, René A. W.
PY - 2017
Y1 - 2017
N2 - +T cell subsets. Hierarchical clustering of the proteomes placed naive and CD45RA-expressing effector-type T cells at the extremes of the spectrum, with central memory and other effector memory stages located in between. Prominent differences between the subsets included expression of specific granzymes, signaling proteins, and molecules involved in metabolic regulation and cell adhesion. Remarkably, whereas most of the proteomic relationships between the subsets occurred in linear variations, a small proportion of proteins was regulated only in discrete subsets. The data obtained from this proteome analysis correspond best to a progressive differentiation model in which specific stable traits are gradually acquired during development
AB - +T cell subsets. Hierarchical clustering of the proteomes placed naive and CD45RA-expressing effector-type T cells at the extremes of the spectrum, with central memory and other effector memory stages located in between. Prominent differences between the subsets included expression of specific granzymes, signaling proteins, and molecules involved in metabolic regulation and cell adhesion. Remarkably, whereas most of the proteomic relationships between the subsets occurred in linear variations, a small proportion of proteins was regulated only in discrete subsets. The data obtained from this proteome analysis correspond best to a progressive differentiation model in which specific stable traits are gradually acquired during development
U2 - https://doi.org/10.1016/j.celrep.2017.04.014
DO - https://doi.org/10.1016/j.celrep.2017.04.014
M3 - Article
C2 - 28467900
SN - 2211-1247
VL - 19
SP - 1068
EP - 1079
JO - Cell reports
JF - Cell reports
IS - 5
ER -