TY - JOUR
T1 - Target-specific paramagnetic and superparamagnetic micelles for molecular MR imaging
AU - Straathof, Roel
AU - Strijkers, Gustav J.
AU - Nicolay, Klaas
PY - 2011
Y1 - 2011
N2 - Treatment of disease can only be effective when timely and accurate diagnosis of the pathology is achieved. More precise diagnosis can be accomplished if the underlying molecular processes involved in the pathology can be imaged in vivo. This is the field of molecular imaging, which aims to visualize cellular function and molecular processes in living organisms in a non-invasive way. With that aim, molecular markers are specifically targeted by imaging contrast agents. Molecular MRI needs powerful targeted contrast agents. For that purpose, target-specific gadolinium-containing paramagnetic and superparamagnetic, iron oxide-based micelles have been developed. Micelles are lipid-based nanoparticles which are biocompatible and carry a high payload of MR contrast-generating agent. The coupling of high-affinity ligands makes the micelles target-specific. Additionally, this lipid-based micelle platform allows for incorporation of contrast generating molecules for other imaging modalities, e.g., fluorescence or nuclear imaging. This permits applications for multiple imaging modalities, making micelles a highly versatile contrast agent
AB - Treatment of disease can only be effective when timely and accurate diagnosis of the pathology is achieved. More precise diagnosis can be accomplished if the underlying molecular processes involved in the pathology can be imaged in vivo. This is the field of molecular imaging, which aims to visualize cellular function and molecular processes in living organisms in a non-invasive way. With that aim, molecular markers are specifically targeted by imaging contrast agents. Molecular MRI needs powerful targeted contrast agents. For that purpose, target-specific gadolinium-containing paramagnetic and superparamagnetic, iron oxide-based micelles have been developed. Micelles are lipid-based nanoparticles which are biocompatible and carry a high payload of MR contrast-generating agent. The coupling of high-affinity ligands makes the micelles target-specific. Additionally, this lipid-based micelle platform allows for incorporation of contrast generating molecules for other imaging modalities, e.g., fluorescence or nuclear imaging. This permits applications for multiple imaging modalities, making micelles a highly versatile contrast agent
U2 - https://doi.org/10.1007/978-1-61779-219-9_34
DO - https://doi.org/10.1007/978-1-61779-219-9_34
M3 - Article
C2 - 21874503
SN - 1064-3745
VL - 771
SP - 691
EP - 715
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -