TY - JOUR
T1 - Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB
AU - Heeman, Fiona
AU - Hendriks, Janine
AU - Lopes Alves, Isadora
AU - Tolboom, Nelleke
AU - van Berckel, Bart N M
AU - Yaqub, Maqsood
AU - Lammertsma, Adriaan A
N1 - Funding Information: This project received funding from the EU/EFPIA Innovative Medicines Initiative (IMI) Joint Undertaking (EMIF grant 115372) and the EU-EFPIA IMI-2 Joint Undertaking (grant 115952). This joint undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA. This communication reflects the views of the authors and neither IMI nor the European Union and EFPIA are liable for any use that may be made of the information contained herein. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - PURPOSE: Moderate-to-high correlations have been reported between the [11C]PiB PET-derived relative tracer delivery rate R1 and relative CBF as measured using [15O]H2O PET, supporting its use as a proxy of relative CBF. As longitudinal PET studies become more common for measuring treatment efficacy or disease progression, it is important to know the intrinsic variability of R1. The purpose of the present study was to determine this through a retrospective data analysis.PROCEDURES: Test-retest data belonging to twelve participants, who underwent two 90 min [11C]PiB PET scans, were retrospectively included. The voxel-based implementation of the two-step simplified reference tissue model with cerebellar grey matter as reference tissue was used to compute R1 images. Next, test-retest variability was calculated, and test and retest R1 measures were compared using linear mixed effect models and a Bland-Altman analysis.RESULTS: Test-retest variability was low across regions (max. 5.8 %), and test and retest measures showed high, significant correlations (R2=0.92, slope=0.98) and a negligible bias (0.69±3.07 %).CONCLUSIONS: In conclusion, the high precision of [11C]PiB R1 suggests suitable applicability for cross-sectional and longitudinal studies.
AB - PURPOSE: Moderate-to-high correlations have been reported between the [11C]PiB PET-derived relative tracer delivery rate R1 and relative CBF as measured using [15O]H2O PET, supporting its use as a proxy of relative CBF. As longitudinal PET studies become more common for measuring treatment efficacy or disease progression, it is important to know the intrinsic variability of R1. The purpose of the present study was to determine this through a retrospective data analysis.PROCEDURES: Test-retest data belonging to twelve participants, who underwent two 90 min [11C]PiB PET scans, were retrospectively included. The voxel-based implementation of the two-step simplified reference tissue model with cerebellar grey matter as reference tissue was used to compute R1 images. Next, test-retest variability was calculated, and test and retest R1 measures were compared using linear mixed effect models and a Bland-Altman analysis.RESULTS: Test-retest variability was low across regions (max. 5.8 %), and test and retest measures showed high, significant correlations (R2=0.92, slope=0.98) and a negligible bias (0.69±3.07 %).CONCLUSIONS: In conclusion, the high precision of [11C]PiB R1 suggests suitable applicability for cross-sectional and longitudinal studies.
KW - Cerebral blood flow
KW - Relative tracer delivery
KW - Test-retest variability
KW - [ C]PiB, Alzheimer’s disease
UR - http://www.scopus.com/inward/record.url?scp=85104852684&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s11307-021-01606-z
DO - https://doi.org/10.1007/s11307-021-01606-z
M3 - Article
C2 - 33884565
SN - 1536-1632
VL - 23
SP - 335
EP - 339
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 3
ER -