The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Rita Alaggio; Catalina Amador; Ioannis Anagnostopoulos; Ayoma D. Attygalle; Iguaracyra Barreto de Oliveira Araujo; Emilio Berti; Govind Bhagat; Anita Maria Borges; Daniel Boyer; Mariarita Calaminici; Amy Chadburn; John K. C. Chan; Wah Cheuk; Wee-Joo Chng; John K. Choi; Shih-Sung Chuang; Sarah E. Coupland; Magdalena Czader; Sandeep S. Dave; Daphne de Jong; Ming-Qing du; Kojo S. Elenitoba-Johnson; Judith Ferry; Julia Geyer; Dita Gratzinger; Joan Guitart; Sumeet Gujral; Marian Harris; Christine J. Harrison; Sylvia Hartmann; Andreas Hochhaus; Patty M. Jansen; Kennosuke Karube; Werner Kempf; Joseph Khoury; Hiroshi Kimura; Wolfram Klapper; Alexandra E. Kovach; Shaji Kumar; Alexander J. Lazar; Stefano Lazzi; Lorenzo Leoncini; Nelson Leung; Vasiliki Leventaki; Xiao-Qiu Li; Megan S. Lim; Wei-Ping Liu; Abner Louissaint; Andrea Marcogliese; L. Jeffrey Medeiros; Michael Michal; Roberto N. Miranda; Christina Mitteldorf; Santiago Montes-Moreno; William Morice; Valentina Nardi; Kikkeri N. Naresh; Yasodha Natkunam; Siok-Bian Ng; Ilske Oschlies; German Ott; Marie Parrens; Melissa Pulitzer; S. Vincent Rajkumar; Andrew C. Rawstron; Karen Rech; Andreas Rosenwald; Jonathan Said; Clémentine Sarkozy; Shahin Sayed; Caner Saygin; Anna Schuh; William Sewell; Reiner Siebert; Aliyah R. Sohani; Reuben Tooze; Alexandra Traverse-Glehen; Francisco Vega; Beatrice Vergier; Ashutosh D. Wechalekar; Brent Wood; Luc Xerri; Wenbin Xiao

doi:https://doi.org/10.1038/s41375-022-01620-2

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Daniel Boyer, Mariarita Calaminici, Amy Chadburn, John K. C. Chan, Wah Cheuk, Wee-Joo Chng, John K. Choi, Shih-Sung Chuang, Sarah E. Coupland, Magdalena Czader, Sandeep S. Dave, Daphne de JongMing-Qing du, Kojo S. Elenitoba-Johnson, Judith Ferry, Julia Geyer, Dita Gratzinger, Joan Guitart, Sumeet Gujral, Marian Harris, Christine J. Harrison, Sylvia Hartmann, Andreas Hochhaus, Patty M. Jansen, Kennosuke Karube, Werner Kempf, Joseph Khoury, Hiroshi Kimura, Wolfram Klapper, Alexandra E. Kovach, Shaji Kumar, Alexander J. Lazar, Stefano Lazzi, Lorenzo Leoncini, Nelson Leung, Vasiliki Leventaki, Xiao-Qiu Li, Megan S. Lim, Wei-Ping Liu, Abner Louissaint, Andrea Marcogliese, L. Jeffrey Medeiros, Michael Michal, Roberto N. Miranda, Christina Mitteldorf, Santiago Montes-Moreno, William Morice, Valentina Nardi, Kikkeri N. Naresh, Yasodha Natkunam, Siok-Bian Ng, Ilske Oschlies, German Ott, Marie Parrens, Melissa Pulitzer, S. Vincent Rajkumar, Andrew C. Rawstron, Karen Rech, Andreas Rosenwald, Jonathan Said, Clémentine Sarkozy, Shahin Sayed, Caner Saygin, Anna Schuh, William Sewell, Reiner Siebert, Aliyah R. Sohani, Reuben Tooze, Alexandra Traverse-Glehen, Francisco Vega, Beatrice Vergier, Ashutosh D. Wechalekar, Brent Wood, Luc Xerri, Wenbin Xiao

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.

Original language	English
Pages (from-to)	1720-1748
Number of pages	29
Journal	Leukemia
Volume	36
Issue number	7
DOIs	https://doi.org/10.1038/s41375-022-01620-2
Publication status	Published - 1 Jul 2022

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Alaggio, R., Amador, C., Anagnostopoulos, I., Attygalle, A. D., Araujo, I. B. D. O., Berti, E., Bhagat, G., Borges, A. M., Boyer, D., Calaminici, M., Chadburn, A., Chan, J. K. C., Cheuk, W., Chng, W.-J., Choi, J. K., Chuang, S.-S., Coupland, S. E., Czader, M., Dave, S. S., ... Xiao, W. (2022). The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia, 36(7), 1720-1748. https://doi.org/10.1038/s41375-022-01620-2

@article{384aab8f467044a2b0dbe546f6e61afc,

title = "The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms",

abstract = "We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.",

author = "Rita Alaggio and Catalina Amador and Ioannis Anagnostopoulos and Attygalle, {Ayoma D.} and Araujo, {Iguaracyra Barreto de Oliveira} and Emilio Berti and Govind Bhagat and Borges, {Anita Maria} and Daniel Boyer and Mariarita Calaminici and Amy Chadburn and Chan, {John K. C.} and Wah Cheuk and Wee-Joo Chng and Choi, {John K.} and Shih-Sung Chuang and Coupland, {Sarah E.} and Magdalena Czader and Dave, {Sandeep S.} and {de Jong}, Daphne and Ming-Qing du and Elenitoba-Johnson, {Kojo S.} and Judith Ferry and Julia Geyer and Dita Gratzinger and Joan Guitart and Sumeet Gujral and Marian Harris and Harrison, {Christine J.} and Sylvia Hartmann and Andreas Hochhaus and Jansen, {Patty M.} and Kennosuke Karube and Werner Kempf and Joseph Khoury and Hiroshi Kimura and Wolfram Klapper and Kovach, {Alexandra E.} and Shaji Kumar and Lazar, {Alexander J.} and Stefano Lazzi and Lorenzo Leoncini and Nelson Leung and Vasiliki Leventaki and Xiao-Qiu Li and Lim, {Megan S.} and Wei-Ping Liu and Abner Louissaint and Andrea Marcogliese and Medeiros, {L. Jeffrey} and Michael Michal and Miranda, {Roberto N.} and Christina Mitteldorf and Santiago Montes-Moreno and William Morice and Valentina Nardi and Naresh, {Kikkeri N.} and Yasodha Natkunam and Siok-Bian Ng and Ilske Oschlies and German Ott and Marie Parrens and Melissa Pulitzer and Rajkumar, {S. Vincent} and Rawstron, {Andrew C.} and Karen Rech and Andreas Rosenwald and Jonathan Said and Cl{\'e}mentine Sarkozy and Shahin Sayed and Caner Saygin and Anna Schuh and William Sewell and Reiner Siebert and Sohani, {Aliyah R.} and Reuben Tooze and Alexandra Traverse-Glehen and Francisco Vega and Beatrice Vergier and Wechalekar, {Ashutosh D.} and Brent Wood and Luc Xerri and Wenbin Xiao",

note = "Funding Information: The authors thank the leadership and staff of the International Agency for Research on Cancer, especially Ms. Asiedua Asante, for her tireless efforts, and also Jasmine Singh and Kim Vu for their expert assistance in graphic presentation of the river plot figures. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jul,

day = "1",

doi = "https://doi.org/10.1038/s41375-022-01620-2",

language = "English",

volume = "36",

pages = "1720--1748",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "7",

}

Alaggio, R, Amador, C, Anagnostopoulos, I, Attygalle, AD, Araujo, IBDO, Berti, E, Bhagat, G, Borges, AM, Boyer, D, Calaminici, M, Chadburn, A, Chan, JKC, Cheuk, W, Chng, W-J, Choi, JK, Chuang, S-S, Coupland, SE, Czader, M, Dave, SS, de Jong, D, du, M-Q, Elenitoba-Johnson, KS, Ferry, J, Geyer, J, Gratzinger, D, Guitart, J, Gujral, S, Harris, M, Harrison, CJ, Hartmann, S, Hochhaus, A, Jansen, PM, Karube, K, Kempf, W, Khoury, J, Kimura, H, Klapper, W, Kovach, AE, Kumar, S, Lazar, AJ, Lazzi, S, Leoncini, L, Leung, N, Leventaki, V, Li, X-Q, Lim, MS, Liu, W-P, Louissaint, A, Marcogliese, A, Medeiros, LJ, Michal, M, Miranda, RN, Mitteldorf, C, Montes-Moreno, S, Morice, W, Nardi, V, Naresh, KN, Natkunam, Y, Ng, S-B, Oschlies, I, Ott, G, Parrens, M, Pulitzer, M, Rajkumar, SV, Rawstron, AC, Rech, K, Rosenwald, A, Said, J, Sarkozy, C, Sayed, S, Saygin, C, Schuh, A, Sewell, W, Siebert, R, Sohani, AR, Tooze, R, Traverse-Glehen, A, Vega, F, Vergier, B, Wechalekar, AD, Wood, B, Xerri, L & Xiao, W 2022, 'The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms', Leukemia, vol. 36, no. 7, pp. 1720-1748. https://doi.org/10.1038/s41375-022-01620-2

TY - JOUR

T1 - The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours

T2 - Lymphoid Neoplasms

AU - Alaggio, Rita

AU - Amador, Catalina

AU - Anagnostopoulos, Ioannis

AU - Attygalle, Ayoma D.

AU - Araujo, Iguaracyra Barreto de Oliveira

AU - Berti, Emilio

AU - Bhagat, Govind

AU - Borges, Anita Maria

AU - Boyer, Daniel

AU - Calaminici, Mariarita

AU - Chadburn, Amy

AU - Chan, John K. C.

AU - Cheuk, Wah

AU - Chng, Wee-Joo

AU - Choi, John K.

AU - Chuang, Shih-Sung

AU - Coupland, Sarah E.

AU - Czader, Magdalena

AU - Dave, Sandeep S.

AU - de Jong, Daphne

AU - du, Ming-Qing

AU - Elenitoba-Johnson, Kojo S.

AU - Ferry, Judith

AU - Geyer, Julia

AU - Gratzinger, Dita

AU - Guitart, Joan

AU - Gujral, Sumeet

AU - Harris, Marian

AU - Harrison, Christine J.

AU - Hartmann, Sylvia

AU - Hochhaus, Andreas

AU - Jansen, Patty M.

AU - Karube, Kennosuke

AU - Kempf, Werner

AU - Khoury, Joseph

AU - Kimura, Hiroshi

AU - Klapper, Wolfram

AU - Kovach, Alexandra E.

AU - Kumar, Shaji

AU - Lazar, Alexander J.

AU - Lazzi, Stefano

AU - Leoncini, Lorenzo

AU - Leung, Nelson

AU - Leventaki, Vasiliki

AU - Li, Xiao-Qiu

AU - Lim, Megan S.

AU - Liu, Wei-Ping

AU - Louissaint, Abner

AU - Marcogliese, Andrea

AU - Medeiros, L. Jeffrey

AU - Michal, Michael

AU - Miranda, Roberto N.

AU - Mitteldorf, Christina

AU - Montes-Moreno, Santiago

AU - Morice, William

AU - Nardi, Valentina

AU - Naresh, Kikkeri N.

AU - Natkunam, Yasodha

AU - Ng, Siok-Bian

AU - Oschlies, Ilske

AU - Ott, German

AU - Parrens, Marie

AU - Pulitzer, Melissa

AU - Rajkumar, S. Vincent

AU - Rawstron, Andrew C.

AU - Rech, Karen

AU - Rosenwald, Andreas

AU - Said, Jonathan

AU - Sarkozy, Clémentine

AU - Sayed, Shahin

AU - Saygin, Caner

AU - Schuh, Anna

AU - Sewell, William

AU - Siebert, Reiner

AU - Sohani, Aliyah R.

AU - Tooze, Reuben

AU - Traverse-Glehen, Alexandra

AU - Vega, Francisco

AU - Vergier, Beatrice

AU - Wechalekar, Ashutosh D.

AU - Wood, Brent

AU - Xerri, Luc

AU - Xiao, Wenbin

N1 - Funding Information: The authors thank the leadership and staff of the International Agency for Research on Cancer, especially Ms. Asiedua Asante, for her tireless efforts, and also Jasmine Singh and Kim Vu for their expert assistance in graphic presentation of the river plot figures. Publisher Copyright: © 2022, The Author(s).

PY - 2022/7/1

Y1 - 2022/7/1

N2 - We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.

AB - We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.

UR - http://www.scopus.com/inward/record.url?scp=85132417699&partnerID=8YFLogxK

U2 - https://doi.org/10.1038/s41375-022-01620-2

DO - https://doi.org/10.1038/s41375-022-01620-2

M3 - Review article

C2 - 35732829

SN - 0887-6924

VL - 36

SP - 1720

EP - 1748

JO - Leukemia

JF - Leukemia

IS - 7

ER -

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

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