The advantageous role of annexin A1 in cardiovascular disease

Renske de Jong, Giovanna Leoni, Maik Drechsler, Oliver Soehnlein

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The inflammatory response protects the human body against infection and injury. However, uncontrolled and unresolved inflammation can lead to tissue damage and chronic inflammatory diseases. Therefore, active resolution of inflammation is essential to restore tissue homeostasis. This review focuses on the pro-resolving molecule annexin A1 (ANXA1) and its derived peptides. Mechanisms instructed by ANXA1 are multidisciplinary and affect leukocytes as well as endothelial cells and tissue resident cells like macrophages and mast cells. ANXA1 has an outstanding role in limiting leukocyte recruitment and different aspects of ANXA1 as modulator of the leukocyte adhesion cascade are discussed here. Additionally, this review details the therapeutic relevance of ANXA1 and its derived peptides in cardiovascular diseases since atherosclerosis stands out as a chronic inflammatory disease with impaired resolution and continuous leukocyte recruitment
Original languageEnglish
Pages (from-to)261-274
JournalCell adhesion & migration
Volume11
Issue number3
Early online date2016
DOIs
Publication statusPublished - 2017

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