The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes

B Drukarch, J Flier, C A M Jongenelen, G Andringa, A N M Schoffelmeer

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22 Citations (Scopus)


Anethole dithiolethione (ADT) is a clinically available, pluripotent antioxidant proposed as a neuroprotectant for Parkinson's disease (PD). Here, using extracts from cultured astrocytes, containing both monoamine oxidase (MAO) A and B activity, we demonstrate that ADT concentration-dependently inhibits MAO-B activity in a clinically relevant concentration range (0.03-30 microM, IC-50 = 0.5 microM) without affecting MAO A activity. Considering the alleged contribution of MAO activity in general, and MAO-B in particular, to oxidative stress and neurodegeneration in PD, our data further support the neuroprotective potential of ADT.

Original languageEnglish
Pages (from-to)593-8
Number of pages6
JournalJournal of Neural Transmission
Issue number5
Publication statusPublished - May 2006


  • Analysis of Variance
  • Anethole Trithione
  • Animals
  • Animals, Newborn
  • Antioxidants
  • Astrocytes
  • Basal Ganglia
  • Cells, Cultured
  • Clorgyline
  • Comparative Study
  • Dose-Response Relationship, Drug
  • Enzyme Activation
  • Journal Article
  • Monoamine Oxidase
  • Monoamine Oxidase Inhibitors
  • Rats

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