The assessment of anorexia in patients with cancer: cut-off values for the FAACT-A/CS and the VAS for appetite: cut-off values for the FAACT-A/CS and the VAS for appetite

S. Blauwhoff-Buskermolen, C. Ruijgrok, R. W. Ostelo, H. C. W. de Vet, H. M. W. Verheul, M. A. E. de van der Schueren, J. A. E. Langius

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Anorexia is a frequently observed symptom in patients with cancer and is associated with limited food intake and decreased quality of life. Diagnostic instruments such as the Anorexia/Cachexia Subscale (A/CS) of the Functional Assessment of Anorexia/Cachexia Therapy (FAACT) questionnaire and the visual analog scale (VAS) for appetite have been recommended in the assessment of anorexia, but validated cut-off values are lacking. This study aimed to obtain cut-off values of these instruments for the assessment of anorexia in patients with cancer. The FAACT-A/CS and the VAS for appetite were administered to patients with cancer before start of chemotherapy. As reference standard for anorexia, two external criteria were used: (1) a cut-off value of ≥2 on the anorexia symptom scale of the EORTC QLQ C-30 and (2) the question "Do you experience a decreased appetite?" (yes/no). ROC curves were used to examine the optimal cut-off values for the FAACT-A/CS and VAS. A total of 273 patients (58 % male; 64.0 ± 10.6 years) were included. The median score on the FAACT-A/CS was 38 (IQR 32-42) points and 77 (IQR 47-93) points on the VAS. Considering both external criteria, the optimal cut-off value for the FAACT-A/CS was ≤37 (sensitivity (se) 80 %, specificity (sp) 81 %, positive predictive value (PV(+)) 79 %, negative predictive value (PV(-)) 82 %) and for the VAS was ≤70 (se 76 %, sp 83 %, PV(+) 80 %, PV(-) 79 %). For the assessment of anorexia in patients with cancer, our study suggests cut-off values of ≤37 for the FAACT-A/CS and ≤70 for the VAS. Future studies should confirm our findings in other patient samples
Original languageEnglish
Pages (from-to)661-666
Number of pages6
JournalSupportive Care in Cancer
Issue number2
Publication statusPublished - Feb 2016


  • Anorexia
  • Appetite
  • Cancer
  • Cross-Sectional Studies
  • Cut-off values
  • Female
  • Humans
  • Journal Article
  • Male
  • Middle Aged
  • Neoplasms
  • Quality of Life
  • Questionnaire
  • Surveys and Questionnaires
  • Visual Analog Scale

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