TY - JOUR
T1 - The association between apathy, decline in physical performance, and falls in older persons
AU - Henstra, Marieke J.
AU - Rhebergen, Didi
AU - Stek, Max L.
AU - Swart, Karin M. A.
AU - van Dijk, Suzanne C.
AU - Zillikens, M. Carola
AU - Oliai Araghi, Sadaf
AU - de Groot, Lisette C. M. G. M.
AU - van Schoor, Natasja M.
AU - van der Velde, Nathalie
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Symptoms of apathy are common in older persons. Negative effects on physical performance and fall risk are plausible, considering the pathophysiology of apathy. However, literature is scarce. Aim: To longitudinally assess the association between apathy and (1) decline of physical performance and (2) the number of falls in older community-dwelling persons. Methods: The ‘B vitamins for the PRevention Of Osteoporotic Fractures’ study provided data on 2919 older persons over a period of 2 years. Apathy was assessed using the Geriatric Depression Scale 3. A physical performance score (PPS) was calculated using three performance tests. Falls were registered prospectively. We calculated adjusted odds ratios (ORs), Incidence Rate Ratios (IRRs), and their 95% confidence intervals. Effect modification by age and gender was investigated. We also investigated mediation by baseline PPS for the association between apathy and the number of falls. Results: Apathy and decline of PPS were independently associated. After stratification, the effect only remained in men. Age was an effect modifier; higher ORs for decreasing age. Apathy was also independently associated with the number of falls. After stratification, women had higher IRRs than men. Age modified the association in the opposite direction: higher IRRs for increasing age. Baseline PPS was a mediator in the association. Conclusion: The impact of apathy on physical performance and fall incidents varied with age and gender. Potentially, in older individuals with apathy, fall risk is preceded by a decline in physical performance. In clinical practice, identifying apathy in older persons might be useful to target mobility preserving interventions.
AB - Background: Symptoms of apathy are common in older persons. Negative effects on physical performance and fall risk are plausible, considering the pathophysiology of apathy. However, literature is scarce. Aim: To longitudinally assess the association between apathy and (1) decline of physical performance and (2) the number of falls in older community-dwelling persons. Methods: The ‘B vitamins for the PRevention Of Osteoporotic Fractures’ study provided data on 2919 older persons over a period of 2 years. Apathy was assessed using the Geriatric Depression Scale 3. A physical performance score (PPS) was calculated using three performance tests. Falls were registered prospectively. We calculated adjusted odds ratios (ORs), Incidence Rate Ratios (IRRs), and their 95% confidence intervals. Effect modification by age and gender was investigated. We also investigated mediation by baseline PPS for the association between apathy and the number of falls. Results: Apathy and decline of PPS were independently associated. After stratification, the effect only remained in men. Age was an effect modifier; higher ORs for decreasing age. Apathy was also independently associated with the number of falls. After stratification, women had higher IRRs than men. Age modified the association in the opposite direction: higher IRRs for increasing age. Baseline PPS was a mediator in the association. Conclusion: The impact of apathy on physical performance and fall incidents varied with age and gender. Potentially, in older individuals with apathy, fall risk is preceded by a decline in physical performance. In clinical practice, identifying apathy in older persons might be useful to target mobility preserving interventions.
KW - Apathy
KW - Community-dwelling
KW - Fall risk factor
KW - Older persons
KW - Physical performance
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059517759&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30600489
U2 - https://doi.org/10.1007/s40520-018-1096-5
DO - https://doi.org/10.1007/s40520-018-1096-5
M3 - Article
C2 - 30600489
SN - 1594-0667
VL - 31
SP - 1491
EP - 1499
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 10
ER -