TY - JOUR
T1 - The association between overall and abdominal adiposity and depressive mood
T2 - A cross-sectional analysis in 6459 participants
AU - Alshehri, Tahani
AU - Boone, Sebastiaan
AU - de Mutsert, Renée
AU - Penninx, Brenda
AU - Rosendaal, Frits
AU - le Cessie, Saskia
AU - Milaneschi, Yuri
AU - Mook-Kanamori, Dennis
PY - 2019
Y1 - 2019
N2 - Objective: We aimed to evaluate the association between measures of adiposity with depressive mood and specific depressive symptoms. Methods: This study was performed in the Netherlands Epidemiology of Obesity (NEO) study, a population-based study that consists of 6671 middle-aged individuals. We examined the association between measures of overall adiposity (BMI and total body fat), and abdominal adiposity (waist circumference and visceral adipose tissue), with depressive mood severity subgroups and 30 depressive symptoms. Multinomial logistic regression was performed adjusting for potential confounding. Results: Measures of adiposity were associated with depressive mood in a graded fashion. Total body fat showed the strongest association with mild (Odds Ratio (OR): 1.59 per standard deviation, 95% Confidence Interval (95% CI): 1.41–1.80) and moderate to very severe (OR: 1.97, 95% CI: 1.59–2.44) depressive mood. Regarding individual symptoms of depressive mood, total body fat was associated with most depressive symptoms (strongest associations for hyperphagia and fatigability). Conclusions: In the general population, overall and abdominal adiposity measures were associated with depressive mood. This association encompasses most of the depressive symptoms and appeared to be the strongest with specific ‘’atypical’’ neurovegetative symptoms, which may be an indication of an alteration in the energy homeostasis.
AB - Objective: We aimed to evaluate the association between measures of adiposity with depressive mood and specific depressive symptoms. Methods: This study was performed in the Netherlands Epidemiology of Obesity (NEO) study, a population-based study that consists of 6671 middle-aged individuals. We examined the association between measures of overall adiposity (BMI and total body fat), and abdominal adiposity (waist circumference and visceral adipose tissue), with depressive mood severity subgroups and 30 depressive symptoms. Multinomial logistic regression was performed adjusting for potential confounding. Results: Measures of adiposity were associated with depressive mood in a graded fashion. Total body fat showed the strongest association with mild (Odds Ratio (OR): 1.59 per standard deviation, 95% Confidence Interval (95% CI): 1.41–1.80) and moderate to very severe (OR: 1.97, 95% CI: 1.59–2.44) depressive mood. Regarding individual symptoms of depressive mood, total body fat was associated with most depressive symptoms (strongest associations for hyperphagia and fatigability). Conclusions: In the general population, overall and abdominal adiposity measures were associated with depressive mood. This association encompasses most of the depressive symptoms and appeared to be the strongest with specific ‘’atypical’’ neurovegetative symptoms, which may be an indication of an alteration in the energy homeostasis.
KW - Abdominal fat
KW - Body fat distribution
KW - Body mass index
KW - Depression
KW - Depressive disorder
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85072263053&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.psyneuen.2019.104429
DO - https://doi.org/10.1016/j.psyneuen.2019.104429
M3 - Article
C2 - 31526909
SN - 0306-4530
VL - 110
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
M1 - 104429
ER -