The association between wearable device metrics and clinical outcomes in oncology: A systematic review with evidence synthesis and meta-analysis

Milan Kos, Calvin G. Brouwer, Hanneke W. M. van Laarhoven, Maria T. E. Hopman, Martijn G. H. van Oijen, Laurien M. Buffart

Research output: Contribution to journalReview articleAcademicpeer-review

5 Citations (Scopus)


Background: The emerging study of wearable devices (WDs) in patients with cancer provides opportunities to harness real-time patient data for predicting clinical outcomes. We conducted a systematic review with best evidence synthesis to examine the association between WD metrics and clinical outcomes in patients with cancer. Methods: MEDLINE and Embase were searched from inception until June 2022. Risk of bias assessment and best evidence synthesis were performed and, If possible, meta-analysis was conducted. Results: A total of 34 studies was included. We found moderate-to-strong evidence for associations between circadian rest-activity metrics and OS. Disrupted I<O was associated with increased hazard for death (HR 2.08; 95 %CI: 1.50–2.88). For most associations there was insufficient evidence due to lack of studies (n = 32) or inconsistent results (n = 14). Conclusion: Meta-analysis was greatly hampered due to heterogeneity and different methodology used between studies. Studies primarily designed to investigate the association between WD metrics and clinical outcomes are warranted.

Original languageEnglish
Article number103979
JournalCritical Reviews in Oncology/Hematology
Publication statusPublished - 1 May 2023


  • Cancer treatment
  • Circadian rhythm
  • Hospitalization
  • Physical activity
  • Survival
  • Wearable devices

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