TY - JOUR
T1 - The association of coronary lumen volume to left ventricle mass ratio with myocardial blood flow and fractional flow reserve
AU - van Diemen, P. A.
AU - Schumacher, S. P.
AU - Bom, M. J.
AU - Driessen, R. S.
AU - Everaars, H.
AU - Stuijfzand, W. J.
AU - Raijmakers, P. G.
AU - van de Ven, P. M.
AU - Min, J. K.
AU - Leipsic, J. A.
AU - Knuuti, J.
AU - Boellaard, R.
AU - Taylor, C. A.
AU - van Rossum, A. C.
AU - Danad, I.
AU - Knaapen, P.
PY - 2019
Y1 - 2019
N2 - Background: A diminished coronary lumen volume to left ventricle mass ratio (V/M) derived from coronary computed tomography angiography (CCTA) has been proposed as factor contributing to impaired myocardial blood flow (MBF) even in the absence of obstructive disease on invasive coronary angiography (ICA). Methods: Patients underwent CCTA, and positron emission tomography (PET) prior to ICA. Matched global V/M, global, and vessel specific hyperaemic MBF (hMBF), coronary flow reserve (CFR), and, FFR were available for 431 vessels in 152 patients. The median V/M (20.71 mm3/g) was used to divide the population into patients with either a low V/M or a high V/M. Results: Overall, a higher percentage of vessels with an abnormal hMBF and FFR (34% vs. 19%, p = 0.009 and 20% vs. 9%, p = 0.004), as well as a lower FFR (0.93 [interquartile range: 0.85–0.97] vs. 0.95 [0.89–0.98], p = 0.016) values were observed in the low V/M group. V/M was weakly associated with vessel specific hMBF (R = 0.148, p = 0.027), and FFR (R = 0.156, p < 0.001). Among vessels with non-obstructive CAD on ICA (361 vessels), no association between V/M and vessel specific hMBF nor CFR was noted. However, in the absence of obstructive CAD, V/M was associated with (R = 0.081, p = 0.027), and independently predictive for FFR (p = 0.047). Conclusion: Overall, an abnormal vessel specific hMBF and FFR were more prevalent in patients with a low V/M compared to those with a high V/M. Furthermore, V/M was weakly associated with vessel specific hMBF and FFR. In the absence of obstructive CAD on ICA, V/M was weakly associated with notwithstanding independently predictive for FFR.
AB - Background: A diminished coronary lumen volume to left ventricle mass ratio (V/M) derived from coronary computed tomography angiography (CCTA) has been proposed as factor contributing to impaired myocardial blood flow (MBF) even in the absence of obstructive disease on invasive coronary angiography (ICA). Methods: Patients underwent CCTA, and positron emission tomography (PET) prior to ICA. Matched global V/M, global, and vessel specific hyperaemic MBF (hMBF), coronary flow reserve (CFR), and, FFR were available for 431 vessels in 152 patients. The median V/M (20.71 mm3/g) was used to divide the population into patients with either a low V/M or a high V/M. Results: Overall, a higher percentage of vessels with an abnormal hMBF and FFR (34% vs. 19%, p = 0.009 and 20% vs. 9%, p = 0.004), as well as a lower FFR (0.93 [interquartile range: 0.85–0.97] vs. 0.95 [0.89–0.98], p = 0.016) values were observed in the low V/M group. V/M was weakly associated with vessel specific hMBF (R = 0.148, p = 0.027), and FFR (R = 0.156, p < 0.001). Among vessels with non-obstructive CAD on ICA (361 vessels), no association between V/M and vessel specific hMBF nor CFR was noted. However, in the absence of obstructive CAD, V/M was associated with (R = 0.081, p = 0.027), and independently predictive for FFR (p = 0.047). Conclusion: Overall, an abnormal vessel specific hMBF and FFR were more prevalent in patients with a low V/M compared to those with a high V/M. Furthermore, V/M was weakly associated with vessel specific hMBF and FFR. In the absence of obstructive CAD on ICA, V/M was weakly associated with notwithstanding independently predictive for FFR.
KW - Coronary arterial lumen volume to left ventricle mass ratio
KW - Coronary artery disease
KW - Coronary computed tomography angiography
KW - Fractional flow reserve
KW - Positron emission tomography
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068501900&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31302027
U2 - https://doi.org/10.1016/j.jcct.2019.06.016
DO - https://doi.org/10.1016/j.jcct.2019.06.016
M3 - Article
C2 - 31302027
SN - 1934-5925
VL - 13
SP - 179
EP - 187
JO - Journal of cardiovascular computed tomography
JF - Journal of cardiovascular computed tomography
IS - 4
ER -